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- W1991261331 abstract "l-Dopa and apomorphine are active drugs used in the treatment of patients suffering from Parkinson's disease (PD), a neurodegenerative disease in which the dopaminergic pathway involved in the regulation of behavioral and sensorimotor functions is severely impaired. The mechanisms involved are still poorly understood; however, a recent study has demonstrated that the level of expectation of benefit from treatment might influence and enhance the endogenous release of dopamine from the nigralstriatal pathway independently of the efficacy of the drug. In order to evaluate the power of the placebo effect in PD, researchers have studied the binding of the competitive dopamine receptor ligand [11C] raclopride by PET scanning. Patients receiving placebo or active drug showed comparably less binding of RAC in the striatum, indicating endogenous release of dopamine. The results published in Science (293, 1164–1166) highlight the importance of placebo controls in evaluating therapeutical intervention. SS" @default.
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- W1991261331 date "2001-11-01" @default.
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- W1991261331 title "The power of belief" @default.
- W1991261331 doi "https://doi.org/10.1016/s0166-2236(00)02049-x" @default.
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