FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991266013> ?p ?o ?g. }

• W1991266013 endingPage "70" @default.
• W1991266013 startingPage "66" @default.
• W1991266013 abstract "Dihydropyrimidine dehydrogenase (DPD) is an enzyme that catabolizes 5-fluorouracil (5-FU). The effect of DPD inhibitory fluoropyrimidines (DIF) is presumably related to DPD activity. We studied the efficacy of DIF (tegafur + uracil [UFT], tegafur + gimeracil + osteracil [S-1 (TS-1®)]) relative to DPD activity, with other fluoropyrimidines as controls. The efficacy of DIF relative to DPD activity was evaluated in 58 gastric cancer patients who received postoperative administration of fluoropyrimidines, consisting of DIF in 42 patients (UFT in 23; S-1 in 19) and non-DIF in 16 patients. In patients with low DPD activity (under 40 U/mg protein), curative potential tended to be lower for DIF than for non-DIF, but the survival rate was the same for both. In patients with high DPD activity (40 U/mg protein or more), such a tendency was not detected. In a comparison between those treated with UFT and those treated with S-1, prognosis was better in the latter group, in spite of their predominance of lower curative potentials of B or C. In 27 patients with measurable lesions, a partial response (PR) or higher response occurred in 33% (5/15) of those with low DPD activity, and in 17% (2/12) of those with high DPD activity. In the patients with low DPD activity, non-DIF induced no change (NC) in 17% (1/6), and progressive disease (PD) in the rest. UFT induced PD in all 5 patients, while S-1 induced a response rate of 44% (7/16), with NC in 25% (4/16). In the patients with high DPD activity, on the other hand, non-DIF (n = 3) and UFT (n = 3) induced PD in all the patients, while S-1 induced PR in 33% (2/6) and NC or a higher response in 67% (4/6). It is recommended to use S-1 rather than UFT in patients with high DPD activity. Measurement of DPD was useful in drug selection." @default.
• W1991266013 created "2016-06-24" @default.
• W1991266013 creator A5009412161 @default.
• W1991266013 creator A5010365288 @default.
• W1991266013 creator A5023435471 @default.
• W1991266013 creator A5025984729 @default.
• W1991266013 creator A5049548789 @default.
• W1991266013 creator A5058116139 @default.
• W1991266013 creator A5059096563 @default.
• W1991266013 creator A5077522059 @default.
• W1991266013 creator A5083952519 @default.
• W1991266013 date "2003-04-01" @default.
• W1991266013 modified "2023-09-26" @default.
• W1991266013 title "Dihydropyrimidine dehydrogenase (DPD) activity in gastric cancer tissue and effect of DPD inhibitory fluoropyrimidines" @default.
• W1991266013 cites W1488362191 @default.
• W1991266013 cites W1622475365 @default.
• W1991266013 cites W1863898801 @default.
• W1991266013 cites W1878265365 @default.
• W1991266013 cites W1979110171 @default.
• W1991266013 cites W1985463875 @default.
• W1991266013 cites W2077902459 @default.
• W1991266013 cites W2090941375 @default.
• W1991266013 cites W2267143225 @default.
• W1991266013 cites W2397419887 @default.
• W1991266013 cites W2409196403 @default.
• W1991266013 cites W2411424148 @default.
• W1991266013 cites W2429989668 @default.
• W1991266013 cites W61003746 @default.
• W1991266013 doi "https://doi.org/10.1007/s10120-003-0225-8" @default.
• W1991266013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12775023" @default.
• W1991266013 hasPublicationYear "2003" @default.
• W1991266013 type Work @default.
• W1991266013 sameAs 1991266013 @default.
• W1991266013 citedByCount "10" @default.
• W1991266013 countsByYear W19912660132016 @default.
• W1991266013 countsByYear W19912660132020 @default.
• W1991266013 crossrefType "journal-article" @default.
• W1991266013 hasAuthorship W1991266013A5009412161 @default.
• W1991266013 hasAuthorship W1991266013A5010365288 @default.
• W1991266013 hasAuthorship W1991266013A5023435471 @default.
• W1991266013 hasAuthorship W1991266013A5025984729 @default.
• W1991266013 hasAuthorship W1991266013A5049548789 @default.
• W1991266013 hasAuthorship W1991266013A5058116139 @default.
• W1991266013 hasAuthorship W1991266013A5059096563 @default.
• W1991266013 hasAuthorship W1991266013A5077522059 @default.
• W1991266013 hasAuthorship W1991266013A5083952519 @default.
• W1991266013 hasBestOaLocation W19912660131 @default.
• W1991266013 hasConcept C121608353 @default.
• W1991266013 hasConcept C123321153 @default.
• W1991266013 hasConcept C126322002 @default.
• W1991266013 hasConcept C185592680 @default.
• W1991266013 hasConcept C2777299880 @default.
• W1991266013 hasConcept C2778050828 @default.
• W1991266013 hasConcept C2779554091 @default.
• W1991266013 hasConcept C2780140570 @default.
• W1991266013 hasConcept C2780456651 @default.
• W1991266013 hasConcept C552990157 @default.
• W1991266013 hasConcept C55493867 @default.
• W1991266013 hasConcept C71924100 @default.
• W1991266013 hasConcept C90924648 @default.
• W1991266013 hasConceptScore W1991266013C121608353 @default.
• W1991266013 hasConceptScore W1991266013C123321153 @default.
• W1991266013 hasConceptScore W1991266013C126322002 @default.
• W1991266013 hasConceptScore W1991266013C185592680 @default.
• W1991266013 hasConceptScore W1991266013C2777299880 @default.
• W1991266013 hasConceptScore W1991266013C2778050828 @default.
• W1991266013 hasConceptScore W1991266013C2779554091 @default.
• W1991266013 hasConceptScore W1991266013C2780140570 @default.
• W1991266013 hasConceptScore W1991266013C2780456651 @default.
• W1991266013 hasConceptScore W1991266013C552990157 @default.
• W1991266013 hasConceptScore W1991266013C55493867 @default.
• W1991266013 hasConceptScore W1991266013C71924100 @default.
• W1991266013 hasConceptScore W1991266013C90924648 @default.
• W1991266013 hasIssue "S1" @default.
• W1991266013 hasLocation W19912660131 @default.
• W1991266013 hasLocation W19912660132 @default.
• W1991266013 hasOpenAccess W1991266013 @default.
• W1991266013 hasPrimaryLocation W19912660131 @default.
• W1991266013 hasRelatedWork W1567245404 @default.
• W1991266013 hasRelatedWork W1977544717 @default.
• W1991266013 hasRelatedWork W1981473858 @default.
• W1991266013 hasRelatedWork W2030264902 @default.
• W1991266013 hasRelatedWork W2044499173 @default.
• W1991266013 hasRelatedWork W2071092546 @default.
• W1991266013 hasRelatedWork W2097212313 @default.
• W1991266013 hasRelatedWork W2415454968 @default.
• W1991266013 hasRelatedWork W4251977626 @default.
• W1991266013 hasRelatedWork W4252269214 @default.
• W1991266013 hasVolume "6" @default.
• W1991266013 isParatext "false" @default.
• W1991266013 isRetracted "false" @default.
• W1991266013 magId "1991266013" @default.
• W1991266013 workType "article" @default.