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- W1991273870 abstract "We read with interest Dr. Anand’s Editorial View, “Anesthetic Neurotoxicity in Newborns: Should We Change Clinical Practice?” but we are concerned that readers may misinterpret his indication regarding postnatal day 35 (P35) rhesus monkeys: “anesthetic neurotoxicity primarily results from apoptosis in rodents, … whereas infant monkeys at P5 (but not at P35) exhibit both excitotoxicity and apoptosis.”1Although the report referenced by Dr. Anand in regard to P35 monkeys did not find a neurotoxic effect, it used one control and one experimental sample of n = 3.2For each indicator of neurotoxicity, the SDs bracketing the observed results were far greater than the observed difference between the control group and the anesthetized group, such that a confidence interval around each observed difference includes levels of neurotoxicity that cannot be dismissed. Accordingly, the neurotoxicity of anesthetics has not been established beyond age P5 in a primate model. Absence of evidence is (still) not evidence of absence.3*State University of New York, Downstate Medical Center, Brooklyn, New York. john.hartung@downstate.edu" @default.
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- W1991273870 date "2008-02-01" @default.
- W1991273870 modified "2023-09-27" @default.
- W1991273870 title "Newborns and Anesthetic Neurotoxicity" @default.
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- W1991273870 doi "https://doi.org/10.1097/01.anes.0000299837.64607.ec" @default.
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