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- W1991290108 abstract "Multiple sclerosis (MS) is a central nervous system-specific inflammatory and demyelinating disease where a myelin-directed autoimmune response is thought to be pathogenetically relevant. Myelin oligodendrocyte glycoprotein (MOG) is a surface-exposed minor myelin component that is a prime candidate autoantigen. We have investigated peripheral blood lymphocyte responses to synthetic 15 – 26 amino acids long overlapping MOG peptides in 20 MS patients and 14 healthy controls with the MS-associated HLA haplotype DR2(15). There were significantly increased responses, in terms of numbers of cells secreting IFN-γ detected by Elispot in response to several MOG-derived peptides in the MS patients, but not the healthy controls. MOG peptide 63 – 87 evoked the strongest response, and the stimulatory property of this peptide was confirmed in additional DR2(15)+ MS patients where a peptide concentration-dependent proliferative response, which was inhibited by the addition of anti-HLA class II antibodies, was observed. This is the first work detailing putative immunodominant T cell epitopes of MOG in DR2(15)+ MS patients." @default.
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- W1991290108 date "1998-10-01" @default.
- W1991290108 modified "2023-10-18" @default.
- W1991290108 title "Increased reactivity to myelin oligodendrocyte glycoprotein peptides and epitope mapping in HLA DR2(15)+ multiple sclerosis" @default.
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- W1991290108 doi "https://doi.org/10.1002/(sici)1521-4141(199810)28:10<3329::aid-immu3329>3.0.co;2-b" @default.
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