Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991309074> ?p ?o ?g. }
- W1991309074 endingPage "e61970" @default.
- W1991309074 startingPage "e61970" @default.
- W1991309074 abstract "Pulmonate snails have remarkably high levels of mtDNA polymorphism within species and divergence between species, making them an interesting group for the study of mutation and selection on mitochondrial genomes. The availability of sequence data from most major lineages - collected largely for studies of phylogeography - provides an opportunity to perform several tests of selection that may provide general insights into the evolutionary forces that have produced this unusual pattern. Several protein coding mtDNA datasets of pulmonates were analyzed towards this direction. Two different methods for the detection of positive selection were used, one based on phylogeny, and the other on the McDonald-Kreitman test. The cyto-nuclear coevolution hypothesis, often implicated to account for the high levels of mtDNA divergence of some organisms, was also addressed by assessing the divergence pattern exhibited by a nuclear gene. The McDonald-Kreitman test indicated multiple signs of positive selection in the mtDNA genes, but was significantly biased when sequence divergence was high. The phylogenetic method identified five mtDNA datasets as affected by positive selection. In the nuclear gene, the McDonald-Kreitman test provided no significant results, whereas the phylogenetic method identified positive selection as likely present. Overall, our findings indicate that: 1) slim support for the cyto-nuclear coevolution hypothesis is present, 2) the elevated rates of mtDNA polymorphims and divergence in pulmonates do not appear to be due to pervasive positive selection, 3) more stringent tests show that spurious positive selection is uncovered when distant taxa are compared and 4) there are significant examples of positive selection acting in some cases, so it appears that mtDNA evolution in pulmonates can escape from strict deleterious evolution suggested by the Muller's ratchet effect." @default.
- W1991309074 created "2016-06-24" @default.
- W1991309074 creator A5041097296 @default.
- W1991309074 creator A5065274278 @default.
- W1991309074 creator A5075299457 @default.
- W1991309074 date "2013-04-19" @default.
- W1991309074 modified "2023-09-26" @default.
- W1991309074 title "Animal Mitochondria, Positive Selection and Cyto-Nuclear Coevolution: Insights from Pulmonates" @default.
- W1991309074 cites W1509397261 @default.
- W1991309074 cites W1519038743 @default.
- W1991309074 cites W1525734744 @default.
- W1991309074 cites W1548851995 @default.
- W1991309074 cites W1563884654 @default.
- W1991309074 cites W1574961512 @default.
- W1991309074 cites W1596515083 @default.
- W1991309074 cites W1605857527 @default.
- W1991309074 cites W1832024365 @default.
- W1991309074 cites W1923211028 @default.
- W1991309074 cites W1926122783 @default.
- W1991309074 cites W1939590947 @default.
- W1991309074 cites W1953801165 @default.
- W1991309074 cites W1964343732 @default.
- W1991309074 cites W1965090926 @default.
- W1991309074 cites W1969821378 @default.
- W1991309074 cites W1970703423 @default.
- W1991309074 cites W1971337156 @default.
- W1991309074 cites W1978080359 @default.
- W1991309074 cites W1979682410 @default.
- W1991309074 cites W1982603712 @default.
- W1991309074 cites W1982972392 @default.
- W1991309074 cites W1983297759 @default.
- W1991309074 cites W1991582059 @default.
- W1991309074 cites W1993927518 @default.
- W1991309074 cites W1994475550 @default.
- W1991309074 cites W1995246242 @default.
- W1991309074 cites W2000832848 @default.
- W1991309074 cites W2003903026 @default.
- W1991309074 cites W2004097398 @default.
- W1991309074 cites W2005049692 @default.
- W1991309074 cites W2005968597 @default.
- W1991309074 cites W2006467919 @default.
- W1991309074 cites W2009352704 @default.
- W1991309074 cites W2010421268 @default.
- W1991309074 cites W2010775509 @default.
- W1991309074 cites W2010863401 @default.
- W1991309074 cites W2012288025 @default.
- W1991309074 cites W2024188955 @default.
- W1991309074 cites W2024239836 @default.
- W1991309074 cites W2025874449 @default.
- W1991309074 cites W2026509565 @default.
- W1991309074 cites W2029134836 @default.
- W1991309074 cites W2031566388 @default.
- W1991309074 cites W2031876907 @default.
- W1991309074 cites W2032437386 @default.
- W1991309074 cites W2036346930 @default.
- W1991309074 cites W2036427790 @default.
- W1991309074 cites W2038576371 @default.
- W1991309074 cites W2039958682 @default.
- W1991309074 cites W2040441669 @default.
- W1991309074 cites W2041326122 @default.
- W1991309074 cites W2042948314 @default.
- W1991309074 cites W2049737678 @default.
- W1991309074 cites W2057456873 @default.
- W1991309074 cites W2057538311 @default.
- W1991309074 cites W2061819685 @default.
- W1991309074 cites W2065461553 @default.
- W1991309074 cites W2065940515 @default.
- W1991309074 cites W2067929169 @default.
- W1991309074 cites W2072262249 @default.
- W1991309074 cites W2074793120 @default.
- W1991309074 cites W2077810335 @default.
- W1991309074 cites W2079103974 @default.
- W1991309074 cites W2079951804 @default.
- W1991309074 cites W2082501734 @default.
- W1991309074 cites W2083268591 @default.
- W1991309074 cites W2086291372 @default.
- W1991309074 cites W2089985991 @default.
- W1991309074 cites W2090200043 @default.
- W1991309074 cites W2090928159 @default.
- W1991309074 cites W2093016244 @default.
- W1991309074 cites W2093622519 @default.
- W1991309074 cites W2097977090 @default.
- W1991309074 cites W2100945428 @default.
- W1991309074 cites W2103170242 @default.
- W1991309074 cites W2104096640 @default.
- W1991309074 cites W2104952200 @default.
- W1991309074 cites W2105381419 @default.
- W1991309074 cites W2105462580 @default.
- W1991309074 cites W2106385649 @default.
- W1991309074 cites W2107986426 @default.
- W1991309074 cites W2108738426 @default.
- W1991309074 cites W2110335151 @default.
- W1991309074 cites W2125121305 @default.
- W1991309074 cites W2125400823 @default.
- W1991309074 cites W2128630175 @default.
- W1991309074 cites W2129135891 @default.
- W1991309074 cites W2129666171 @default.
- W1991309074 cites W2133585817 @default.