Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991312167> ?p ?o ?g. }
- W1991312167 endingPage "68" @default.
- W1991312167 startingPage "63" @default.
- W1991312167 abstract "Activated platelet-specific autoreactive T cells play a key role in the pathophysiology of immune thrombocytopenia (ITP). Tolerogenic dendritic cells (tDCs) that induce T cells tolerance to platelet autoantigens are a promising strategy for specific cellular therapy in autoimmunity. In this study, we generated three kinds of GPIIb-specific tDCs stimulated by IL-10 (10-DCs), TGFβ1 (T-DCs), or a combination of IL-10 and TGFβ1 (10T-DCs), respectively, and compared their phenotypes and biological function. Our data demonstrate that GPIIb-specific 10T-DCs induced the weakest memory lymphocytes responses and exhibited stronger tolerogenic potential than others, making them suitable for tolerance inducing therapies. Furthermore, in ITP mice model we found that 10T-DCs abrogated the decrease in platelet counts and the increase in serum IFN-γ level, confirming the in vivo tolerogenic potential of 10T-DCs. Our study provides a promising strategy for ITP intervention in the clinic by the induction of platelet-specific immune tolerance." @default.
- W1991312167 created "2016-06-24" @default.
- W1991312167 creator A5000953326 @default.
- W1991312167 creator A5003799076 @default.
- W1991312167 creator A5005268235 @default.
- W1991312167 creator A5026909840 @default.
- W1991312167 creator A5039018137 @default.
- W1991312167 creator A5051356913 @default.
- W1991312167 creator A5056036725 @default.
- W1991312167 creator A5062161921 @default.
- W1991312167 date "2013-07-01" @default.
- W1991312167 modified "2023-09-27" @default.
- W1991312167 title "Tolerogenic dendritic cells generated with IL-10/TGFβ1 relieve immune thrombocytopenia in mice" @default.
- W1991312167 cites W1562592996 @default.
- W1991312167 cites W1566390556 @default.
- W1991312167 cites W1602276647 @default.
- W1991312167 cites W1638979393 @default.
- W1991312167 cites W1869403232 @default.
- W1991312167 cites W1931833667 @default.
- W1991312167 cites W1970177550 @default.
- W1991312167 cites W1970574917 @default.
- W1991312167 cites W1971071236 @default.
- W1991312167 cites W1983662907 @default.
- W1991312167 cites W1993142414 @default.
- W1991312167 cites W1994426347 @default.
- W1991312167 cites W1999380172 @default.
- W1991312167 cites W1999918831 @default.
- W1991312167 cites W2012543138 @default.
- W1991312167 cites W2014207233 @default.
- W1991312167 cites W2043982114 @default.
- W1991312167 cites W2044781881 @default.
- W1991312167 cites W2047941152 @default.
- W1991312167 cites W2060862592 @default.
- W1991312167 cites W2061024246 @default.
- W1991312167 cites W2096953466 @default.
- W1991312167 cites W2099190435 @default.
- W1991312167 cites W2110719788 @default.
- W1991312167 cites W2138702511 @default.
- W1991312167 cites W2140734388 @default.
- W1991312167 cites W2141391781 @default.
- W1991312167 cites W2144110774 @default.
- W1991312167 cites W2147671732 @default.
- W1991312167 cites W2155997720 @default.
- W1991312167 cites W2160824801 @default.
- W1991312167 cites W2164386465 @default.
- W1991312167 cites W90886090 @default.
- W1991312167 doi "https://doi.org/10.1016/j.thromres.2013.04.001" @default.
- W1991312167 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23602734" @default.
- W1991312167 hasPublicationYear "2013" @default.
- W1991312167 type Work @default.
- W1991312167 sameAs 1991312167 @default.
- W1991312167 citedByCount "13" @default.
- W1991312167 countsByYear W19913121672013 @default.
- W1991312167 countsByYear W19913121672014 @default.
- W1991312167 countsByYear W19913121672015 @default.
- W1991312167 countsByYear W19913121672016 @default.
- W1991312167 countsByYear W19913121672019 @default.
- W1991312167 countsByYear W19913121672020 @default.
- W1991312167 countsByYear W19913121672021 @default.
- W1991312167 countsByYear W19913121672022 @default.
- W1991312167 crossrefType "journal-article" @default.
- W1991312167 hasAuthorship W1991312167A5000953326 @default.
- W1991312167 hasAuthorship W1991312167A5003799076 @default.
- W1991312167 hasAuthorship W1991312167A5005268235 @default.
- W1991312167 hasAuthorship W1991312167A5026909840 @default.
- W1991312167 hasAuthorship W1991312167A5039018137 @default.
- W1991312167 hasAuthorship W1991312167A5051356913 @default.
- W1991312167 hasAuthorship W1991312167A5056036725 @default.
- W1991312167 hasAuthorship W1991312167A5062161921 @default.
- W1991312167 hasConcept C203014093 @default.
- W1991312167 hasConcept C2777701055 @default.
- W1991312167 hasConcept C2777702733 @default.
- W1991312167 hasConcept C2778170410 @default.
- W1991312167 hasConcept C2780130043 @default.
- W1991312167 hasConcept C71924100 @default.
- W1991312167 hasConcept C8891405 @default.
- W1991312167 hasConcept C89560881 @default.
- W1991312167 hasConceptScore W1991312167C203014093 @default.
- W1991312167 hasConceptScore W1991312167C2777701055 @default.
- W1991312167 hasConceptScore W1991312167C2777702733 @default.
- W1991312167 hasConceptScore W1991312167C2778170410 @default.
- W1991312167 hasConceptScore W1991312167C2780130043 @default.
- W1991312167 hasConceptScore W1991312167C71924100 @default.
- W1991312167 hasConceptScore W1991312167C8891405 @default.
- W1991312167 hasConceptScore W1991312167C89560881 @default.
- W1991312167 hasIssue "1" @default.
- W1991312167 hasLocation W19913121671 @default.
- W1991312167 hasLocation W19913121672 @default.
- W1991312167 hasOpenAccess W1991312167 @default.
- W1991312167 hasPrimaryLocation W19913121671 @default.
- W1991312167 hasRelatedWork W1967938261 @default.
- W1991312167 hasRelatedWork W1984674482 @default.
- W1991312167 hasRelatedWork W1988960013 @default.
- W1991312167 hasRelatedWork W1996053215 @default.
- W1991312167 hasRelatedWork W1996150995 @default.
- W1991312167 hasRelatedWork W2017013532 @default.
- W1991312167 hasRelatedWork W2096287500 @default.
- W1991312167 hasRelatedWork W2135448752 @default.