FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991323714> ?p ?o ?g. }

• W1991323714 endingPage "629" @default.
• W1991323714 startingPage "622" @default.
• W1991323714 abstract "Many clinicians are reluctant to prescribe inhaled corticosteroids because of concerns over potential effects on the hypothalamic-pituitary-adrenal axis.The purpose of this study was to compare the adrenal responses to 6-hour cosyntropin infusion after treatment with fluticasone propionate aerosol, triamcinolone acetonide aerosol, prednisone, and placebo for 4 weeks, a sufficient time interval to assess any effects on the adrenal response to stress.This double-blind, triple-dummy, randomized, placebo-controlled study was conducted in 128 patients to evaluate adrenal response to 6-hour cosyntropin infusion (a clinically relevant method for evaluating adrenal function) after 28 days of treatment with fluticasone propionate aerosol 88 microg or 220 microg twice daily, triamcinolone acetonide aerosol 200 microg 4 times daily or 400 microg twice daily, prednisone 10 mg once daily, and placebo.After 28 days of treatment, mean plasma cortisol response to cosyntropin over 12 hours after initiation of the 6-hour infusion was similar among fluticasone, triamcinolone, and placebo groups; cortisol response was significantly (P <.05) reduced after treatment with prednisone compared with the other treatment groups. Mean 8-hour area under the plasma cortisol concentration-time curves and peak plasma cortisol concentrations were significantly (P </=.003) lower with prednisone than any other treatment; no significant differences were noted between placebo and either of the fluticasone groups in any assessment. Mean reductions from baseline in area under the plasma cortisol concentration time curves and peak cortisol concentrations were significantly (P <.05) greater with triamcinolone 400 microg twice daily compared with placebo.These results suggest that fluticasone propionate at therapeutic doses has effects on the hypothalamic-pituitary-adrenal axis comparable to that of placebo and has significantly less effect than prednisone as measured by 6-hour cosyntropin infusion after 28 days of treatment." @default.
• W1991323714 created "2016-06-24" @default.
• W1991323714 creator A5029708109 @default.
• W1991323714 creator A5047450563 @default.
• W1991323714 creator A5053401241 @default.
• W1991323714 creator A5057208475 @default.
• W1991323714 creator A5062406720 @default.
• W1991323714 creator A5067604175 @default.
• W1991323714 creator A5080266308 @default.
• W1991323714 creator A5088001027 @default.
• W1991323714 date "1999-04-01" @default.
• W1991323714 modified "2023-09-26" @default.
• W1991323714 title "Effects of fluticasone propionate, triamcinolone acetonide, prednisone, and placebo on the hypothalamic-pituitary-adrenal axis" @default.
• W1991323714 cites W1492890516 @default.
• W1991323714 cites W1984135011 @default.
• W1991323714 cites W2020716977 @default.
• W1991323714 cites W2027601069 @default.
• W1991323714 cites W2032750747 @default.
• W1991323714 cites W2039423598 @default.
• W1991323714 cites W2062997955 @default.
• W1991323714 cites W2077438160 @default.
• W1991323714 cites W2083556417 @default.
• W1991323714 cites W2092350658 @default.
• W1991323714 cites W2095449166 @default.
• W1991323714 cites W2129005018 @default.
• W1991323714 cites W2134062936 @default.
• W1991323714 cites W2151871224 @default.
• W1991323714 cites W2153657940 @default.
• W1991323714 cites W2161430604 @default.
• W1991323714 cites W2169940583 @default.
• W1991323714 cites W4236639597 @default.
• W1991323714 cites W4254972446 @default.
• W1991323714 doi "https://doi.org/10.1016/s0091-6749(99)70234-4" @default.
• W1991323714 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10200011" @default.
• W1991323714 hasPublicationYear "1999" @default.
• W1991323714 type Work @default.
• W1991323714 sameAs 1991323714 @default.
• W1991323714 citedByCount "33" @default.
• W1991323714 countsByYear W19913237142013 @default.
• W1991323714 countsByYear W19913237142014 @default.
• W1991323714 countsByYear W19913237142015 @default.
• W1991323714 countsByYear W19913237142017 @default.
• W1991323714 countsByYear W19913237142019 @default.
• W1991323714 crossrefType "journal-article" @default.
• W1991323714 hasAuthorship W1991323714A5029708109 @default.
• W1991323714 hasAuthorship W1991323714A5047450563 @default.
• W1991323714 hasAuthorship W1991323714A5053401241 @default.
• W1991323714 hasAuthorship W1991323714A5057208475 @default.
• W1991323714 hasAuthorship W1991323714A5062406720 @default.
• W1991323714 hasAuthorship W1991323714A5067604175 @default.
• W1991323714 hasAuthorship W1991323714A5080266308 @default.
• W1991323714 hasAuthorship W1991323714A5088001027 @default.
• W1991323714 hasConcept C126322002 @default.
• W1991323714 hasConcept C134018914 @default.
• W1991323714 hasConcept C141071460 @default.
• W1991323714 hasConcept C142724271 @default.
• W1991323714 hasConcept C204787440 @default.
• W1991323714 hasConcept C27081682 @default.
• W1991323714 hasConcept C2776804153 @default.
• W1991323714 hasConcept C2778720950 @default.
• W1991323714 hasConcept C2778903070 @default.
• W1991323714 hasConcept C2779028295 @default.
• W1991323714 hasConcept C2780546910 @default.
• W1991323714 hasConcept C2781212218 @default.
• W1991323714 hasConcept C2908704050 @default.
• W1991323714 hasConcept C42219234 @default.
• W1991323714 hasConcept C71315377 @default.
• W1991323714 hasConcept C71924100 @default.
• W1991323714 hasConceptScore W1991323714C126322002 @default.
• W1991323714 hasConceptScore W1991323714C134018914 @default.
• W1991323714 hasConceptScore W1991323714C141071460 @default.
• W1991323714 hasConceptScore W1991323714C142724271 @default.
• W1991323714 hasConceptScore W1991323714C204787440 @default.
• W1991323714 hasConceptScore W1991323714C27081682 @default.
• W1991323714 hasConceptScore W1991323714C2776804153 @default.
• W1991323714 hasConceptScore W1991323714C2778720950 @default.
• W1991323714 hasConceptScore W1991323714C2778903070 @default.
• W1991323714 hasConceptScore W1991323714C2779028295 @default.
• W1991323714 hasConceptScore W1991323714C2780546910 @default.
• W1991323714 hasConceptScore W1991323714C2781212218 @default.
• W1991323714 hasConceptScore W1991323714C2908704050 @default.
• W1991323714 hasConceptScore W1991323714C42219234 @default.
• W1991323714 hasConceptScore W1991323714C71315377 @default.
• W1991323714 hasConceptScore W1991323714C71924100 @default.
• W1991323714 hasIssue "4" @default.
• W1991323714 hasLocation W19913237141 @default.
• W1991323714 hasLocation W19913237142 @default.
• W1991323714 hasOpenAccess W1991323714 @default.
• W1991323714 hasPrimaryLocation W19913237141 @default.
• W1991323714 hasRelatedWork W1965631018 @default.
• W1991323714 hasRelatedWork W1991323714 @default.
• W1991323714 hasRelatedWork W1997753653 @default.
• W1991323714 hasRelatedWork W2002266949 @default.
• W1991323714 hasRelatedWork W2071084457 @default.
• W1991323714 hasRelatedWork W2071691143 @default.
• W1991323714 hasRelatedWork W2077438160 @default.
• W1991323714 hasRelatedWork W2094132710 @default.
• W1991323714 hasRelatedWork W2507952836 @default.

• next