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• W1991325368 abstract "Calcium and vitamin D have been implicated in the development of type 2 diabetes, but epidemiological evidence is limited. We examined prospectively the relation of calcium and vitamin D intake to type 2 diabetes risk in a Japanese cohort. Participants were 59,796 middle-aged and older men and women, who participated in the Japan Public Health Center-based Prospective Study and had no history of type 2 diabetes or other serious diseases. Dietary intake of calcium and vitamin D were estimated using a validated food frequency questionnaire. Logistic regression was used to assess the association between intake of these nutrients and self-reported newly diagnosed type 2 diabetes. During a 5 year follow-up, 1,114 cases of type 2 diabetes were documented. Overall, calcium intake was not associated with a significantly lower risk of type 2 diabetes; the multivariable odds ratio for the highest vs lowest quartiles was 0.93 (95% CI 0.71–1.22) in men and 0.76 (95% CI 0.56–1.03) in women. However, among participants with a higher vitamin D intake, calcium intake was inversely associated with diabetes risk; the odds ratio for the highest vs lowest intake categories was 0.62 (95% CI 0.41–0.94) in men and 0.59 (95% CI 0.38–0.91) in women. Dairy food intake was significantly associated with a lower risk of type 2 diabetes in women only. Calcium and vitamin D may not be independently associated with type 2 diabetes risk. Our finding suggesting a joint action of these nutrients against type 2 diabetes warrants further investigation." @default.
• W1991325368 created "2016-06-24" @default.
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• W1991325368 date "2009-10-13" @default.
• W1991325368 modified "2023-09-25" @default.
• W1991325368 title "Calcium, vitamin D and dairy intake in relation to type 2 diabetes risk in a Japanese cohort" @default.
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• W1991325368 doi "https://doi.org/10.1007/s00125-009-1554-x" @default.
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