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• W1991328715 abstract "Motivated by our recent study showing improved flow and dissolution rate of the active pharmaceutical ingredient (API) powders (20 μm) produced via simultaneous micronization and surface modification through continuous fluid energy milling (FEM) process, the performance of blends and direct compacted tablets with high drug loading is examined. Performance of 50 μm API powders dry coated without micronization is also considered for comparison. Blends of micronized, non-micronized, dry coated or uncoated API powders at 30, 60 and 70% drug loading, are examined. The results show that the blends containing dry coated API powders, even micronized ones, have excellent flowability and high bulk density compared to the blends containing uncoated API, which are required for direct compaction. As the drug loading increases, the difference between dry coated and uncoated blends is more pronounced, as seen in the proposed bulk density-FFC phase map. Dry coating led to improved tablet compactibility profiles, corresponding with the improvements in blend compressibility. The most significant advantage is in tablet dissolution where for all drug loadings, the t80 for the tablets with dry coated APIs was well under 5 min, indicating that this approach can produce nearly instant release direct compacted tablets at high drug loadings." @default.
• W1991328715 created "2016-06-24" @default.
• W1991328715 creator A5001100343 @default.
• W1991328715 creator A5005311880 @default.
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• W1991328715 date "2013-02-01" @default.
• W1991328715 modified "2023-09-26" @default.
• W1991328715 title "Dry coating of micronized API powders for improved dissolution of directly compacted tablets with high drug loading" @default.
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• W1991328715 doi "https://doi.org/10.1016/j.ijpharm.2012.08.004" @default.
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• W1991328715 hasPublicationYear "2013" @default.
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