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- W1991335334 abstract "Underdosing of the treatment target in radiation therapy can occur when tumors are situated near natural air cavities due to charged particle disequilibrium around air‐tissue interfaces. These effects increase with energy and decrease with radiationfield size. Significant underdosing may occur with small field sizes, which may be critical for IMRT and tomotherapy techniques, which employ radiation beamlets of varying intensities to deliverconformal radiation therapy. Cobalt‐60 based tomotherapy has been suggested as a clinically and commercially viable alternative to 6MV linac based approaches. The work presented here is undertaken to explore potential reduction in interface underdosing with Co‐60 based tomotherapy due to lower beam energy. The Monte‐Carlo simulations using EGSnrc/DOSXYZnrc code were performed for single, parallel opposed and four beams of Co‐60 γ‐rays, and 6MV and 15MV x‐rays. The radiation fields were varied in size from small beamlets of 2×2cm2 to large fields up to 9×9cm2. The doses were scored near the air‐water interfaces for the air cavity of sizes 1×1×1cm3, 3×3×3cm3 and 5×5×5cm3 centered within a 20×20×20cm3water phantom in 2×2×2mm3 voxels and compared with doses in homogeneous water phantom. In all situations, no significant interface underdosing is observed for 1×1×1cm3cavity or where radiation beam is comparable or larger than the cavity size. The interface underdosing decreases with an increase in the numbers and size of the radiation beams, and increases with energy. Significant interface underdosing is observed for small beams. Co‐60 simulations show significantly less underdosing near the interfaces than that with 6MV and 15MV beams." @default.
- W1991335334 created "2016-06-24" @default.
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- W1991335334 date "2005-06-23" @default.
- W1991335334 modified "2023-10-03" @default.
- W1991335334 title "Po-Poster - 11: Interface dosimetry around air cavities for cobalt-60, 6MV and 15MV beams using EGSnrc/DOSXYZnrc Monte-Carlo simulation" @default.
- W1991335334 doi "https://doi.org/10.1118/1.2030990" @default.
- W1991335334 hasPublicationYear "2005" @default.
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