FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991339577> ?p ?o ?g. }

• W1991339577 endingPage "123" @default.
• W1991339577 startingPage "108" @default.
• W1991339577 abstract "<i>Background/Aims:</i> Gastrointestinal (GI) disorders are common adverse reactions of nonsteroidal anti-inflammatory drugs (NSAIDs). Loxoprofen is a representative NSAID widely used in East Asia. A selective cyclooxygenase-2 inhibitor, celecoxib, was introduced in Japan in 2007. In this study, we aimed to compare the efficacy and safety of celecoxib with those of loxoprofen in Japanese patients. <i>Methods:</i> We analyzed the data from 12 clinical studies conducted in Japan. These data of Japanese patients were compared with those of the patients in the West that had been published after 2000. <i>Results:</i> The efficacy of celecoxib as an analgesic was comparable to that of loxoprofen, whereas serious GI events, including symptomatic ulcers, were significantly less frequent with celecoxib than with loxoprofen in Japanese patients with rheumatoid arthritis (RA) and osteoarthritis (OA) (p = 0.039). These results were consistent with the findings of the studies conducted in the West. The incidence of serious cardiovascular events was 0.1% in 2,398 subjects on celecoxib, which was not statistically different from the incidence in subjects on loxoprofen (0.3%; p = 0.3404) and those on placebo (0.2%); this result was also consistent with the data of the studies conducted in the West. <i>Conclusion:</i> The analgesic activity of celecoxib, which was used for the treatment of RA, OA, and low back pain, was comparable to that of loxoprofen, and celecoxib was safer in terms of GI injury often caused by other nonselective NSAIDs." @default.
• W1991339577 created "2016-06-24" @default.
• W1991339577 creator A5073807260 @default.
• W1991339577 creator A5086531834 @default.
• W1991339577 date "2010-11-01" @default.
• W1991339577 modified "2023-10-16" @default.
• W1991339577 title "Efficacy and Safety of the Selective Cyclooxygenase-2 Inhibitor Celecoxib in the Treatment of Rheumatoid Arthritis and Osteoarthritis in Japan" @default.
• W1991339577 cites W1596546277 @default.
• W1991339577 cites W1669654299 @default.
• W1991339577 cites W167603866 @default.
• W1991339577 cites W1867240762 @default.
• W1991339577 cites W1945695150 @default.
• W1991339577 cites W1964443629 @default.
• W1991339577 cites W1969077452 @default.
• W1991339577 cites W1969798546 @default.
• W1991339577 cites W1971207139 @default.
• W1991339577 cites W1972361929 @default.
• W1991339577 cites W1976594978 @default.
• W1991339577 cites W1977473142 @default.
• W1991339577 cites W1979306581 @default.
• W1991339577 cites W1984059952 @default.
• W1991339577 cites W1985210212 @default.
• W1991339577 cites W1988108320 @default.
• W1991339577 cites W1995528018 @default.
• W1991339577 cites W1997364548 @default.
• W1991339577 cites W1999502359 @default.
• W1991339577 cites W2000713608 @default.
• W1991339577 cites W2002178040 @default.
• W1991339577 cites W2010860405 @default.
• W1991339577 cites W2014664456 @default.
• W1991339577 cites W2021041600 @default.
• W1991339577 cites W2021580807 @default.
• W1991339577 cites W2023243818 @default.
• W1991339577 cites W2024233889 @default.
• W1991339577 cites W2030850720 @default.
• W1991339577 cites W2031078761 @default.
• W1991339577 cites W2034013987 @default.
• W1991339577 cites W2038932922 @default.
• W1991339577 cites W2039149640 @default.
• W1991339577 cites W2044267165 @default.
• W1991339577 cites W2045493775 @default.
• W1991339577 cites W2046536696 @default.
• W1991339577 cites W2047208214 @default.
• W1991339577 cites W2054812603 @default.
• W1991339577 cites W2063252400 @default.
• W1991339577 cites W2065748354 @default.
• W1991339577 cites W2067621583 @default.
• W1991339577 cites W2079003073 @default.
• W1991339577 cites W2083464592 @default.
• W1991339577 cites W2083748640 @default.
• W1991339577 cites W2084863173 @default.
• W1991339577 cites W2085680573 @default.
• W1991339577 cites W2088179332 @default.
• W1991339577 cites W2090531910 @default.
• W1991339577 cites W2097780727 @default.
• W1991339577 cites W2098648996 @default.
• W1991339577 cites W2101592854 @default.
• W1991339577 cites W2110739516 @default.
• W1991339577 cites W2111144017 @default.
• W1991339577 cites W2113745276 @default.
• W1991339577 cites W2114949308 @default.
• W1991339577 cites W2117935315 @default.
• W1991339577 cites W2118910625 @default.
• W1991339577 cites W2122435770 @default.
• W1991339577 cites W2123441868 @default.
• W1991339577 cites W2124678826 @default.
• W1991339577 cites W2128939361 @default.
• W1991339577 cites W2132552005 @default.
• W1991339577 cites W2134234269 @default.
• W1991339577 cites W2136555831 @default.
• W1991339577 cites W2144691807 @default.
• W1991339577 cites W2145271885 @default.
• W1991339577 cites W2145839235 @default.
• W1991339577 cites W2147127261 @default.
• W1991339577 cites W2148359829 @default.
• W1991339577 cites W2158131645 @default.
• W1991339577 cites W2158310507 @default.
• W1991339577 cites W2158968701 @default.
• W1991339577 cites W2159106700 @default.
• W1991339577 cites W2161097107 @default.
• W1991339577 cites W2163756514 @default.
• W1991339577 cites W2164290354 @default.
• W1991339577 cites W2167792025 @default.
• W1991339577 cites W2168733098 @default.
• W1991339577 cites W2172253009 @default.
• W1991339577 cites W2313437711 @default.
• W1991339577 cites W2333044470 @default.
• W1991339577 cites W2346641421 @default.
• W1991339577 cites W2547668515 @default.
• W1991339577 cites W2404491145 @default.
• W1991339577 cites W2600516270 @default.
• W1991339577 cites W66574010 @default.
• W1991339577 doi "https://doi.org/10.1159/000318746" @default.
• W1991339577 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21042022" @default.
• W1991339577 hasPublicationYear "2010" @default.
• W1991339577 type Work @default.
• W1991339577 sameAs 1991339577 @default.
• W1991339577 citedByCount "45" @default.

• next