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• W1991340498 startingPage "7695" @default.
• W1991340498 abstract "2-Pyridones were prepared from 2,6-dibromopyridine via a multi-step synthesis. A variety of chemical transformations, including regioselective nucleophilic addition and selective nitrogen alkylation, afforded the penultimate intermediate 9. A combination of two-dimensional NMR techniques to unequivocally assign the structure of 9 is described. Compound 9 was then used in a Suzuki coupling and further derivatized to afford the targeted tissue Factor VIIa inhibitors. These compounds were tested in several serine protease enzyme assays with biological activity reported." @default.
• W1991340498 created "2016-06-24" @default.
• W1991340498 creator A5060477214 @default.
• W1991340498 creator A5085991833 @default.
• W1991340498 date "2003-09-01" @default.
• W1991340498 modified "2023-09-24" @default.
• W1991340498 title "Synthesis of 2-pyridones as tissue factor VIIa inhibitors" @default.
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• W1991340498 doi "https://doi.org/10.1016/s0040-4020(03)01239-0" @default.
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