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- W1991344211 abstract "Cytotoxic T lymphocytes and natural killer cells use the perforin/granzyme pathway to kill virally infected cells and tumor cells. Mutations in genes important for this pathway are associated with several human diseases. CD4+ T regulatory (Treg) cells have emerged as important in the control of immunopathological processes. We have previously shown that human adaptive Treg cells preferentially express granzyme B and can kill allogeneic target cells in a perforin-dependent manner. Here, we demonstrate that activated human CD4+CD25+ natural Treg cells express granzyme A but very little granzyme B. Furthermore, both Treg subtypes display perforin-dependent cytotoxicity against autologous target cells, including activated CD4+ and CD8+ T cells, CD14+ monocytes, and both immature and mature dendritic cells. This cytotoxicity is dependent on CD18 adhesive interactions but is independent of Fas/FasL. Our findings suggest that the perforin/granzyme pathway is one of the mechanisms that Treg cells can use to control immune responses." @default.
- W1991344211 created "2016-06-24" @default.
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- W1991344211 date "2004-10-01" @default.
- W1991344211 modified "2023-10-16" @default.
- W1991344211 title "Human T Regulatory Cells Can Use the Perforin Pathway to Cause Autologous Target Cell Death" @default.
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- W1991344211 doi "https://doi.org/10.1016/j.immuni.2004.09.002" @default.
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