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• W1991344629 endingPage "3361" @default.
• W1991344629 startingPage "3351" @default.
• W1991344629 abstract "The REF/ALY mRNA export adaptor binds TAP/NXF1 via an arginine-rich region, which overlaps with its RNA-binding domain. When TAP binds a REF:RNA complex, it triggers transfer of the RNA from REF to TAP. Here, we have examined the effects of arginine methylation on the activities of the REF protein in mRNA export. We have mapped the arginine methylation sites of REF using mass spectrometry and find that several arginines within the TAP and RNA binding domains are methylated in vivo. However, arginine methylation has no effect on the REF:TAP interaction. Instead, arginine methylation reduces the RNA-binding activity of REF in vitro and in vivo. The reduced RNA-binding activity of REF in its methylated state is essential for efficient displacement of RNA from REF by TAP in vivo. Therefore, arginine methylation fine-tunes the RNA-binding activity of REF such that the RNA-protein interaction can be readily disrupted by export factors further down the pathway." @default.
• W1991344629 created "2016-06-24" @default.
• W1991344629 creator A5025842714 @default.
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• W1991344629 creator A5043498560 @default.
• W1991344629 creator A5044077432 @default.
• W1991344629 creator A5064049854 @default.
• W1991344629 date "2010-02-02" @default.
• W1991344629 modified "2023-10-06" @default.
• W1991344629 title "Arginine methylation of REF/ALY promotes efficient handover of mRNA to TAP/NXF1" @default.
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• W1991344629 doi "https://doi.org/10.1093/nar/gkq033" @default.
• W1991344629 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2879514" @default.
• W1991344629 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20129943" @default.
• W1991344629 hasPublicationYear "2010" @default.
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