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• W1991344795 abstract "The first total synthesis of the indole alkaloids (±)-aplicyanins A, B, and E, plus 17 analogues, all in racemic form, is reported. Modifications to the parent compound included changing the number of bromine substituents on the indole, the nature of the substituents on the indole nitrogen (H, Me, or OMe), and/or the oxidation level of the heterocyclic core tetrahydropyrimidine. Each compound was screened against three human tumor cell lines, and 14 of the newly synthesized compounds showed considerable cytotoxicity. The assay results were used to establish structure−activity relationships. These results suggest that the presence of the bromine at position 5 of the indole is critical to activity, as well as the acetyl group on the imine nitrogen does in some compounds." @default.
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• W1991344795 date "2009-09-18" @default.
• W1991344795 modified "2023-10-10" @default.
• W1991344795 title "Total Synthesis and Antiproliferative Activity Screening of (±)-Aplicyanins A, B and E and Related Analogues" @default.
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• W1991344795 doi "https://doi.org/10.1021/jm900544z" @default.
• W1991344795 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19827832" @default.
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