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• W1991345824 abstract "Dopamine (DA) is a key neuromodulator in the brain that supports motor and cognitive functions. Here, we use apomorphine (Apo) and 3,3'-iminodipropionitrile (IDPN) to develop two rat models of Tourette's syndrome (TS), a common neuropsychiatric disorder characterized by stereotyped repetitive involuntary tics. The models enabled the assessment of unique ameliorative effects of Ningdong granule (NDG), a traditional Chinese medicine (TCM) preparation dedicated to the treatment of TS, on the striatal DA content of rats. By using high-performance liquid chromatography (HPLC), we found that long-term administration of NDG could, at least partially, restore the striatal dopamine alterations, either by increasing them after IDPN treatment or by decreasing them after Apo treatment. Taken together, our data indicated that NDG could ameliorate the abnormal striatal DA content dually and the unique therapeutic property may be meaningful for the treatment of TS." @default.
• W1991345824 created "2016-06-24" @default.
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• W1991345824 creator A5048718607 @default.
• W1991345824 date "2015-01-16" @default.
• W1991345824 modified "2023-10-16" @default.
• W1991345824 title "Dual ameliorative effects of Ningdong granule on dopamine in rat models of Tourette's syndrome" @default.
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• W1991345824 doi "https://doi.org/10.1038/srep07731" @default.
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