FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991362023> ?p ?o ?g. }

• W1991362023 endingPage "10899" @default.
• W1991362023 startingPage "10887" @default.
• W1991362023 abstract "Lack of oxidative stress control is a common and often prime feature observed in many neurodegenerative diseases. Both DJ-1 and SOD1, proteins involved in familial Parkinson disease and amyotrophic lateral sclerosis, respectively, play a protective role against oxidative stress. Impaired activity and modified expression of both proteins have been observed in different neurodegenerative diseases. A potential cooperative action of DJ-1 and SOD1 in the same oxidative stress response pathway may be suggested based on a copper-mediated interaction between the two proteins reported here. To investigate the mechanisms underlying the antioxidative function of DJ-1 in relation to SOD1 activity, we investigated the ability of DJ-1 to bind copper ions. We structurally characterized a novel copper binding site involving Cys-106, and we investigated, using different techniques, the kinetics of DJ-1 binding to copper ions. The copper transfer between the two proteins was also examined using both fluorescence spectroscopy and specific biochemical assays for SOD1 activity. The structural and functional analysis of the novel DJ-1 copper binding site led us to identify a putative role for DJ-1 as a copper chaperone. Alteration of the coordination geometry of the copper ion in DJ-1 may be correlated to the physiological role of the protein, to a potential failure in metal transfer to SOD1, and to successive implications in neurodegenerative etiopathogenesis." @default.
• W1991362023 created "2016-06-24" @default.
• W1991362023 creator A5007819316 @default.
• W1991362023 creator A5010366987 @default.
• W1991362023 creator A5012780698 @default.
• W1991362023 creator A5018522294 @default.
• W1991362023 creator A5030303785 @default.
• W1991362023 creator A5084055615 @default.
• W1991362023 creator A5091519952 @default.
• W1991362023 date "2014-04-01" @default.
• W1991362023 modified "2023-10-07" @default.
• W1991362023 title "DJ-1 Is a Copper Chaperone Acting on SOD1 Activation" @default.
• W1991362023 cites W1509038183 @default.
• W1991362023 cites W1546589453 @default.
• W1991362023 cites W1585758755 @default.
• W1991362023 cites W1940436875 @default.
• W1991362023 cites W1969665448 @default.
• W1991362023 cites W1974104912 @default.
• W1991362023 cites W1975452827 @default.
• W1991362023 cites W1976393002 @default.
• W1991362023 cites W1976600619 @default.
• W1991362023 cites W1978163054 @default.
• W1991362023 cites W1987118718 @default.
• W1991362023 cites W1988215967 @default.
• W1991362023 cites W1988821469 @default.
• W1991362023 cites W1995129249 @default.
• W1991362023 cites W2001641653 @default.
• W1991362023 cites W2020994172 @default.
• W1991362023 cites W2023003247 @default.
• W1991362023 cites W2025153717 @default.
• W1991362023 cites W2026841498 @default.
• W1991362023 cites W2037601979 @default.
• W1991362023 cites W2039474386 @default.
• W1991362023 cites W2044780988 @default.
• W1991362023 cites W2046771108 @default.
• W1991362023 cites W2049288888 @default.
• W1991362023 cites W2059010479 @default.
• W1991362023 cites W2060947179 @default.
• W1991362023 cites W2063089997 @default.
• W1991362023 cites W2065409333 @default.
• W1991362023 cites W2075542239 @default.
• W1991362023 cites W2075579767 @default.
• W1991362023 cites W2078349645 @default.
• W1991362023 cites W2083578247 @default.
• W1991362023 cites W2084953647 @default.
• W1991362023 cites W2090063868 @default.
• W1991362023 cites W2091852463 @default.
• W1991362023 cites W2093329764 @default.
• W1991362023 cites W2093477805 @default.
• W1991362023 cites W2098451745 @default.
• W1991362023 cites W2104382960 @default.
• W1991362023 cites W2105112194 @default.
• W1991362023 cites W2105442888 @default.
• W1991362023 cites W2112552649 @default.
• W1991362023 cites W2119028277 @default.
• W1991362023 cites W2122902319 @default.
• W1991362023 cites W2129755489 @default.
• W1991362023 cites W2133407217 @default.
• W1991362023 cites W2138065616 @default.
• W1991362023 cites W2144081223 @default.
• W1991362023 cites W2157076525 @default.
• W1991362023 cites W2159211495 @default.
• W1991362023 cites W2160681852 @default.
• W1991362023 cites W2171873547 @default.
• W1991362023 cites W2180229411 @default.
• W1991362023 doi "https://doi.org/10.1074/jbc.m113.535112" @default.
• W1991362023 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4036200" @default.
• W1991362023 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24567322" @default.
• W1991362023 hasPublicationYear "2014" @default.
• W1991362023 type Work @default.
• W1991362023 sameAs 1991362023 @default.
• W1991362023 citedByCount "75" @default.
• W1991362023 countsByYear W19913620232014 @default.
• W1991362023 countsByYear W19913620232015 @default.
• W1991362023 countsByYear W19913620232016 @default.
• W1991362023 countsByYear W19913620232017 @default.
• W1991362023 countsByYear W19913620232018 @default.
• W1991362023 countsByYear W19913620232019 @default.
• W1991362023 countsByYear W19913620232020 @default.
• W1991362023 countsByYear W19913620232021 @default.
• W1991362023 countsByYear W19913620232022 @default.
• W1991362023 countsByYear W19913620232023 @default.
• W1991362023 crossrefType "journal-article" @default.
• W1991362023 hasAuthorship W1991362023A5007819316 @default.
• W1991362023 hasAuthorship W1991362023A5010366987 @default.
• W1991362023 hasAuthorship W1991362023A5012780698 @default.
• W1991362023 hasAuthorship W1991362023A5018522294 @default.
• W1991362023 hasAuthorship W1991362023A5030303785 @default.
• W1991362023 hasAuthorship W1991362023A5084055615 @default.
• W1991362023 hasAuthorship W1991362023A5091519952 @default.
• W1991362023 hasBestOaLocation W19913620231 @default.
• W1991362023 hasConcept C12554922 @default.
• W1991362023 hasConcept C126322002 @default.
• W1991362023 hasConcept C142724271 @default.
• W1991362023 hasConcept C178790620 @default.
• W1991362023 hasConcept C185592680 @default.
• W1991362023 hasConcept C2775838275 @default.
• W1991362023 hasConcept C2775962898 @default.

• next