Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991363903> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W1991363903 endingPage "38a" @default.
- W1991363903 startingPage "38a" @default.
- W1991363903 abstract "Protein, DNA, and RNA shape, assembly and interactions shapes, plus their detailed structural chemistry, encode key information regarding pathway choices and biological outcomes. We are developing SAXS combined with crystallography as a premiere tool for defining macromolecular conformations and connections suitable to join proteins to pathways and at the proteomic scale1-2. Crystallography supplies unsurpassed structural detail for mechanistic analyses; however, it is restricted to describing conformations of macromolecules within crystal lattices. In principle, SAXS can provide reliable complementary data on small and large macromolecules3. In practice, SAXS can be limited by problems in optimizing samples and analyses, which can be reduced or avoided. Our results on dynamic RNA, DNA, and protein complexes show that SAXS has great potential to provide accurate shapes, conformations, and assembly states in solution and inform biological functions in fundamental ways4-5. 1. Hura, GL et al., & Tainer, JA (2009) Rapid and robust proteomics-scale solution structural analyses determined efficiently by x-ray scattering (SAXS), Nature Methods 6: 606-612. 2. Rambo RP, Tainer JA (2010) Improving small-angle X-ray scattering data for structural analyses of the RNA world, RNA 16: 638-646. 3. Rambo RP, Tainer JA (2010) Bridging the solution divide: comprehensive structural analyses of dynamic RNA, DNA, and protein assemblies by small-angle X-ray scattering, Current Opinion Structural Biol. 20:128-137. 4. Williams RS, et al., & Tainer JA (2009). Nbs1 flexibly tethers Ctp1 and Mre11-Rad50 to coordinate DNA double-strand break processing and repair, Cell 139: 87-99. 5. Hammel M et al., & Tainer JA (2010) Ku and DNA-dependent protein kinase (DNA-PK) dynamic conformations and assembly regulate DNA binding and the initial non-homollogous end joining complex, J. Biol. Chem. 285: 1414-1423." @default.
- W1991363903 created "2016-06-24" @default.
- W1991363903 creator A5059713279 @default.
- W1991363903 date "2011-02-01" @default.
- W1991363903 modified "2023-09-27" @default.
- W1991363903 title "X-Ray Scattering (SAXS) Combined with Crystallography and Computation: Defining Accurate Macromolecular Structures, Conformations and Assemblies in Solution" @default.
- W1991363903 doi "https://doi.org/10.1016/j.bpj.2010.12.409" @default.
- W1991363903 hasPublicationYear "2011" @default.
- W1991363903 type Work @default.
- W1991363903 sameAs 1991363903 @default.
- W1991363903 citedByCount "3" @default.
- W1991363903 countsByYear W19913639032018 @default.
- W1991363903 countsByYear W19913639032019 @default.
- W1991363903 crossrefType "journal-article" @default.
- W1991363903 hasAuthorship W1991363903A5059713279 @default.
- W1991363903 hasBestOaLocation W19913639031 @default.
- W1991363903 hasConcept C104317684 @default.
- W1991363903 hasConcept C11413529 @default.
- W1991363903 hasConcept C120665830 @default.
- W1991363903 hasConcept C121332964 @default.
- W1991363903 hasConcept C131888329 @default.
- W1991363903 hasConcept C185592680 @default.
- W1991363903 hasConcept C191486275 @default.
- W1991363903 hasConcept C204389451 @default.
- W1991363903 hasConcept C41008148 @default.
- W1991363903 hasConcept C45374587 @default.
- W1991363903 hasConcept C552990157 @default.
- W1991363903 hasConcept C55493867 @default.
- W1991363903 hasConcept C67705224 @default.
- W1991363903 hasConcept C70721500 @default.
- W1991363903 hasConcept C8010536 @default.
- W1991363903 hasConcept C86803240 @default.
- W1991363903 hasConceptScore W1991363903C104317684 @default.
- W1991363903 hasConceptScore W1991363903C11413529 @default.
- W1991363903 hasConceptScore W1991363903C120665830 @default.
- W1991363903 hasConceptScore W1991363903C121332964 @default.
- W1991363903 hasConceptScore W1991363903C131888329 @default.
- W1991363903 hasConceptScore W1991363903C185592680 @default.
- W1991363903 hasConceptScore W1991363903C191486275 @default.
- W1991363903 hasConceptScore W1991363903C204389451 @default.
- W1991363903 hasConceptScore W1991363903C41008148 @default.
- W1991363903 hasConceptScore W1991363903C45374587 @default.
- W1991363903 hasConceptScore W1991363903C552990157 @default.
- W1991363903 hasConceptScore W1991363903C55493867 @default.
- W1991363903 hasConceptScore W1991363903C67705224 @default.
- W1991363903 hasConceptScore W1991363903C70721500 @default.
- W1991363903 hasConceptScore W1991363903C8010536 @default.
- W1991363903 hasConceptScore W1991363903C86803240 @default.
- W1991363903 hasIssue "3" @default.
- W1991363903 hasLocation W19913639031 @default.
- W1991363903 hasOpenAccess W1991363903 @default.
- W1991363903 hasPrimaryLocation W19913639031 @default.
- W1991363903 hasRelatedWork W1568607286 @default.
- W1991363903 hasRelatedWork W1981312008 @default.
- W1991363903 hasRelatedWork W2006775363 @default.
- W1991363903 hasRelatedWork W2094265991 @default.
- W1991363903 hasRelatedWork W2118094025 @default.
- W1991363903 hasRelatedWork W2261998615 @default.
- W1991363903 hasRelatedWork W2336936639 @default.
- W1991363903 hasRelatedWork W2413744854 @default.
- W1991363903 hasRelatedWork W2528180298 @default.
- W1991363903 hasRelatedWork W4301972284 @default.
- W1991363903 hasVolume "100" @default.
- W1991363903 isParatext "false" @default.
- W1991363903 isRetracted "false" @default.
- W1991363903 magId "1991363903" @default.
- W1991363903 workType "article" @default.