FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991363982> ?p ?o ?g. }

• W1991363982 endingPage "129" @default.
• W1991363982 startingPage "122" @default.
• W1991363982 abstract "The cells of a weakly tumorigenic and non-metastatic murine fibrosarcoma (QR-32) are converted into highly malignant tumors (acquiring metastatic potential) once they have grown in vivo after being co-implanted with gelatin sponge which induces inflammation. In the present study, we examined whether nitric oxide (NO) is involved in the inflammation-based tumor progression by administrating a specific inhibitor to inducible nitric oxide synthase, aminoguanidine (AG). First, we co-implanted 1 x 10(5) QR-32 cells with gelatin sponge (10 x 5 x 3 mm piece) into a subcutaneous space in C57BL6 mice. Administration of AG in drinking water (1%) had started 2 days before the tumor implantation and continued until the termination of the experiment. The incidence of tumor formation and the tumor growth did not differ between AG-treated group and -untreated group. On day 28, we excised the arising tumors to establish culture cell lines for evaluation of their acquisition of metastatic phenotype in other normal mice. Metastasis incidence and the number of metastatic colonies were significantly reduced in the tumor cell lines obtained from AG-treated mice compared to those from non-treated mice (p < 0.05). Immunohistochemical analysis demonstrated that inducible nitric oxide synthase and nitrotyrosine in the inflamed lesion were reduced in the AG-administered mice. However, intensity of 8-hydroxy-2-deoxyguanosine was not different between the groups. These results showed that nitric oxide and its reactive nitrogen oxide species cooperatively play a pivotal role in the progression of benign tumor cells in inflamed lesions." @default.
• W1991363982 created "2016-06-24" @default.
• W1991363982 creator A5015421086 @default.
• W1991363982 creator A5040453545 @default.
• W1991363982 creator A5042868468 @default.
• W1991363982 creator A5045926215 @default.
• W1991363982 creator A5084948921 @default.
• W1991363982 date "2006-03-01" @default.
• W1991363982 modified "2023-10-17" @default.
• W1991363982 title "Involvement of reactive nitrogen oxides for acquisition of metastatic properties of benign tumors in a model of inflammation-based tumor progression" @default.
• W1991363982 cites W1483898176 @default.
• W1991363982 cites W1484685189 @default.
• W1991363982 cites W1595420782 @default.
• W1991363982 cites W1832498930 @default.
• W1991363982 cites W1966971174 @default.
• W1991363982 cites W1968827777 @default.
• W1991363982 cites W1979388174 @default.
• W1991363982 cites W1981040064 @default.
• W1991363982 cites W1992870310 @default.
• W1991363982 cites W1995277420 @default.
• W1991363982 cites W1995457093 @default.
• W1991363982 cites W2012706488 @default.
• W1991363982 cites W2016456923 @default.
• W1991363982 cites W2018556115 @default.
• W1991363982 cites W2033381628 @default.
• W1991363982 cites W2034946903 @default.
• W1991363982 cites W2037597903 @default.
• W1991363982 cites W2038799463 @default.
• W1991363982 cites W2045727091 @default.
• W1991363982 cites W2047724809 @default.
• W1991363982 cites W2055354965 @default.
• W1991363982 cites W2057830803 @default.
• W1991363982 cites W206141176 @default.
• W1991363982 cites W2067906203 @default.
• W1991363982 cites W2067931227 @default.
• W1991363982 cites W2069178786 @default.
• W1991363982 cites W2072282073 @default.
• W1991363982 cites W2079037244 @default.
• W1991363982 cites W2086321305 @default.
• W1991363982 cites W2094050302 @default.
• W1991363982 cites W2103565638 @default.
• W1991363982 cites W2109853011 @default.
• W1991363982 cites W2116580016 @default.
• W1991363982 cites W2121200953 @default.
• W1991363982 cites W2125690417 @default.
• W1991363982 cites W2128036989 @default.
• W1991363982 cites W2133971451 @default.
• W1991363982 cites W2141415623 @default.
• W1991363982 cites W2149062036 @default.
• W1991363982 cites W2151371305 @default.
• W1991363982 cites W2158418714 @default.
• W1991363982 cites W2171118724 @default.
• W1991363982 cites W2318172046 @default.
• W1991363982 cites W2320554283 @default.
• W1991363982 doi "https://doi.org/10.1016/j.niox.2005.06.009" @default.
• W1991363982 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16125421" @default.
• W1991363982 hasPublicationYear "2006" @default.
• W1991363982 type Work @default.
• W1991363982 sameAs 1991363982 @default.
• W1991363982 citedByCount "19" @default.
• W1991363982 countsByYear W19913639822013 @default.
• W1991363982 countsByYear W19913639822014 @default.
• W1991363982 countsByYear W19913639822015 @default.
• W1991363982 countsByYear W19913639822016 @default.
• W1991363982 countsByYear W19913639822022 @default.
• W1991363982 countsByYear W19913639822023 @default.
• W1991363982 crossrefType "journal-article" @default.
• W1991363982 hasAuthorship W1991363982A5015421086 @default.
• W1991363982 hasAuthorship W1991363982A5040453545 @default.
• W1991363982 hasAuthorship W1991363982A5042868468 @default.
• W1991363982 hasAuthorship W1991363982A5045926215 @default.
• W1991363982 hasAuthorship W1991363982A5084948921 @default.
• W1991363982 hasConcept C121608353 @default.
• W1991363982 hasConcept C126322002 @default.
• W1991363982 hasConcept C142724271 @default.
• W1991363982 hasConcept C150903083 @default.
• W1991363982 hasConcept C185592680 @default.
• W1991363982 hasConcept C204232928 @default.
• W1991363982 hasConcept C207001950 @default.
• W1991363982 hasConcept C2776495794 @default.
• W1991363982 hasConcept C2776914184 @default.
• W1991363982 hasConcept C2777622882 @default.
• W1991363982 hasConcept C2779013556 @default.
• W1991363982 hasConcept C2779256057 @default.
• W1991363982 hasConcept C2779385521 @default.
• W1991363982 hasConcept C502942594 @default.
• W1991363982 hasConcept C519581460 @default.
• W1991363982 hasConcept C71924100 @default.
• W1991363982 hasConcept C86803240 @default.
• W1991363982 hasConceptScore W1991363982C121608353 @default.
• W1991363982 hasConceptScore W1991363982C126322002 @default.
• W1991363982 hasConceptScore W1991363982C142724271 @default.
• W1991363982 hasConceptScore W1991363982C150903083 @default.
• W1991363982 hasConceptScore W1991363982C185592680 @default.
• W1991363982 hasConceptScore W1991363982C204232928 @default.
• W1991363982 hasConceptScore W1991363982C207001950 @default.
• W1991363982 hasConceptScore W1991363982C2776495794 @default.
• W1991363982 hasConceptScore W1991363982C2776914184 @default.

• next