Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991371555> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W1991371555 endingPage "146" @default.
- W1991371555 startingPage "144" @default.
- W1991371555 abstract "Novel delivery technology using cell-penetrating peptides (CPPs) have recently shown their potential and are emerging as promising candidates for an oral protein and peptide delivery systems. As with for the development of any absorption enhancer that is meant to function across an epithelial layer covering a surface highly exposed to pathogens such as the intestines, concern arises about the safety of such enhancers. The purpose of this study was to investigate the effect of 7 d of consecutive oral administrations of CPPs and a typical enterotoxin, lipopolysaccharide (LPS) to mice to determine the degree, if any, of damage caused to the hepatic tissue. Following the 7-d dosing regimen, we could not detect significantly increased levels of the liver enzymes alanine aminotransferase and aspartate aminotransferase in plasma of mice treated with CPP and LPS compared to the controls, whereas heightened levels were observed in animals receiving the bile salt. In conclusion, the repeated use of CPPs as an oral absorption enhancer for macromolecules was found to be a safe strategy." @default.
- W1991371555 created "2016-06-24" @default.
- W1991371555 creator A5000371400 @default.
- W1991371555 creator A5020613069 @default.
- W1991371555 creator A5071851776 @default.
- W1991371555 date "2015-01-01" @default.
- W1991371555 modified "2023-10-06" @default.
- W1991371555 title "Safety of the Cell-Penetrating Peptide Penetratin as an Oral Absorption Enhancer" @default.
- W1991371555 cites W1976767383 @default.
- W1991371555 cites W1984275126 @default.
- W1991371555 cites W1992111884 @default.
- W1991371555 cites W1994632105 @default.
- W1991371555 cites W2008173042 @default.
- W1991371555 cites W2021307619 @default.
- W1991371555 cites W2028178959 @default.
- W1991371555 cites W2033700643 @default.
- W1991371555 cites W2094278454 @default.
- W1991371555 cites W2124131536 @default.
- W1991371555 doi "https://doi.org/10.1248/bpb.b14-00517" @default.
- W1991371555 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25744470" @default.
- W1991371555 hasPublicationYear "2015" @default.
- W1991371555 type Work @default.
- W1991371555 sameAs 1991371555 @default.
- W1991371555 citedByCount "16" @default.
- W1991371555 countsByYear W19913715552015 @default.
- W1991371555 countsByYear W19913715552016 @default.
- W1991371555 countsByYear W19913715552017 @default.
- W1991371555 countsByYear W19913715552018 @default.
- W1991371555 countsByYear W19913715552019 @default.
- W1991371555 countsByYear W19913715552020 @default.
- W1991371555 countsByYear W19913715552021 @default.
- W1991371555 countsByYear W19913715552022 @default.
- W1991371555 crossrefType "journal-article" @default.
- W1991371555 hasAuthorship W1991371555A5000371400 @default.
- W1991371555 hasAuthorship W1991371555A5020613069 @default.
- W1991371555 hasAuthorship W1991371555A5071851776 @default.
- W1991371555 hasBestOaLocation W19913715551 @default.
- W1991371555 hasConcept C104317684 @default.
- W1991371555 hasConcept C111936080 @default.
- W1991371555 hasConcept C121332964 @default.
- W1991371555 hasConcept C125287762 @default.
- W1991371555 hasConcept C150194340 @default.
- W1991371555 hasConcept C185592680 @default.
- W1991371555 hasConcept C24890656 @default.
- W1991371555 hasConcept C2776929087 @default.
- W1991371555 hasConcept C2777056448 @default.
- W1991371555 hasConcept C2779281246 @default.
- W1991371555 hasConcept C55493867 @default.
- W1991371555 hasConcept C71924100 @default.
- W1991371555 hasConcept C98274493 @default.
- W1991371555 hasConceptScore W1991371555C104317684 @default.
- W1991371555 hasConceptScore W1991371555C111936080 @default.
- W1991371555 hasConceptScore W1991371555C121332964 @default.
- W1991371555 hasConceptScore W1991371555C125287762 @default.
- W1991371555 hasConceptScore W1991371555C150194340 @default.
- W1991371555 hasConceptScore W1991371555C185592680 @default.
- W1991371555 hasConceptScore W1991371555C24890656 @default.
- W1991371555 hasConceptScore W1991371555C2776929087 @default.
- W1991371555 hasConceptScore W1991371555C2777056448 @default.
- W1991371555 hasConceptScore W1991371555C2779281246 @default.
- W1991371555 hasConceptScore W1991371555C55493867 @default.
- W1991371555 hasConceptScore W1991371555C71924100 @default.
- W1991371555 hasConceptScore W1991371555C98274493 @default.
- W1991371555 hasIssue "1" @default.
- W1991371555 hasLocation W19913715551 @default.
- W1991371555 hasLocation W19913715552 @default.
- W1991371555 hasOpenAccess W1991371555 @default.
- W1991371555 hasPrimaryLocation W19913715551 @default.
- W1991371555 hasRelatedWork W2156324256 @default.
- W1991371555 hasRelatedWork W2414263157 @default.
- W1991371555 hasRelatedWork W2509907629 @default.
- W1991371555 hasRelatedWork W2579253673 @default.
- W1991371555 hasRelatedWork W2748952813 @default.
- W1991371555 hasRelatedWork W2774790069 @default.
- W1991371555 hasRelatedWork W2793200609 @default.
- W1991371555 hasRelatedWork W2899084033 @default.
- W1991371555 hasRelatedWork W305146918 @default.
- W1991371555 hasRelatedWork W39499931 @default.
- W1991371555 hasVolume "38" @default.
- W1991371555 isParatext "false" @default.
- W1991371555 isRetracted "false" @default.
- W1991371555 magId "1991371555" @default.
- W1991371555 workType "article" @default.