Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991384518> ?p ?o ?g. }
- W1991384518 endingPage "678" @default.
- W1991384518 startingPage "667" @default.
- W1991384518 abstract "Twin-ribozyme introns contain a branching ribozyme (GIR1) followed by a homing endonuclease (HE) encoding sequence embedded in a peripheral domain of a group I splicing ribozyme (GIR2). GIR1 catalyses the formation of a lariat with 3 nt in the loop, which caps the HE mRNA. GIR1 is structurally related to group I ribozymes raising the question about how two closely related ribozymes can carry out very different reactions. Modelling of GIR1 based on new biochemical and mutational data shows an extended substrate domain containing a GoU pair distinct from the nucleophilic residue that dock onto a catalytic core showing a different topology from that of group I ribozymes. The differences include a core J8/7 region that has been reduced and is complemented by residues from the pre-lariat fold. These findings provide the basis for an evolutionary mechanism that accounts for the change from group I splicing ribozyme to the branching GIR1 architecture. Such an evolutionary mechanism can be applied to other large RNAs such as the ribonuclease P." @default.
- W1991384518 created "2016-06-24" @default.
- W1991384518 creator A5018416560 @default.
- W1991384518 creator A5033929684 @default.
- W1991384518 creator A5040070444 @default.
- W1991384518 creator A5081628392 @default.
- W1991384518 creator A5081950003 @default.
- W1991384518 creator A5085113353 @default.
- W1991384518 date "2008-01-24" @default.
- W1991384518 modified "2023-10-11" @default.
- W1991384518 title "Molecular modelling of the GIR1 branching ribozyme gives new insight into evolution of structurally related ribozymes" @default.
- W1991384518 cites W1023810718 @default.
- W1991384518 cites W1489623410 @default.
- W1991384518 cites W1494641947 @default.
- W1991384518 cites W1545020975 @default.
- W1991384518 cites W1573511081 @default.
- W1991384518 cites W1640485157 @default.
- W1991384518 cites W176922563 @default.
- W1991384518 cites W1963925292 @default.
- W1991384518 cites W1969758655 @default.
- W1991384518 cites W1976792261 @default.
- W1991384518 cites W1982825221 @default.
- W1991384518 cites W1984276072 @default.
- W1991384518 cites W1985919704 @default.
- W1991384518 cites W1988633599 @default.
- W1991384518 cites W1993818256 @default.
- W1991384518 cites W1996091651 @default.
- W1991384518 cites W2005408529 @default.
- W1991384518 cites W2007696349 @default.
- W1991384518 cites W2013902881 @default.
- W1991384518 cites W2019934898 @default.
- W1991384518 cites W2028380775 @default.
- W1991384518 cites W2033556990 @default.
- W1991384518 cites W2034252350 @default.
- W1991384518 cites W2035783320 @default.
- W1991384518 cites W2039605602 @default.
- W1991384518 cites W2047683652 @default.
- W1991384518 cites W2049446075 @default.
- W1991384518 cites W2070234025 @default.
- W1991384518 cites W2072656934 @default.
- W1991384518 cites W2077372526 @default.
- W1991384518 cites W2079197003 @default.
- W1991384518 cites W2081451822 @default.
- W1991384518 cites W2082939356 @default.
- W1991384518 cites W2085954575 @default.
- W1991384518 cites W2106478835 @default.
- W1991384518 cites W2107334084 @default.
- W1991384518 cites W2111499892 @default.
- W1991384518 cites W2114616777 @default.
- W1991384518 cites W2123990634 @default.
- W1991384518 cites W2125792673 @default.
- W1991384518 cites W2135575982 @default.
- W1991384518 cites W2146588737 @default.
- W1991384518 cites W2155695277 @default.
- W1991384518 cites W2167955222 @default.
- W1991384518 cites W2168154114 @default.
- W1991384518 cites W2169751581 @default.
- W1991384518 cites W2400721500 @default.
- W1991384518 cites W4237468509 @default.
- W1991384518 doi "https://doi.org/10.1038/emboj.2008.4" @default.
- W1991384518 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2219692" @default.
- W1991384518 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18219270" @default.
- W1991384518 hasPublicationYear "2008" @default.
- W1991384518 type Work @default.
- W1991384518 sameAs 1991384518 @default.
- W1991384518 citedByCount "24" @default.
- W1991384518 countsByYear W19913845182012 @default.
- W1991384518 countsByYear W19913845182013 @default.
- W1991384518 countsByYear W19913845182014 @default.
- W1991384518 countsByYear W19913845182015 @default.
- W1991384518 countsByYear W19913845182016 @default.
- W1991384518 countsByYear W19913845182020 @default.
- W1991384518 countsByYear W19913845182021 @default.
- W1991384518 crossrefType "journal-article" @default.
- W1991384518 hasAuthorship W1991384518A5018416560 @default.
- W1991384518 hasAuthorship W1991384518A5033929684 @default.
- W1991384518 hasAuthorship W1991384518A5040070444 @default.
- W1991384518 hasAuthorship W1991384518A5081628392 @default.
- W1991384518 hasAuthorship W1991384518A5081950003 @default.
- W1991384518 hasAuthorship W1991384518A5085113353 @default.
- W1991384518 hasBestOaLocation W19913845184 @default.
- W1991384518 hasConcept C104317684 @default.
- W1991384518 hasConcept C107745601 @default.
- W1991384518 hasConcept C118346598 @default.
- W1991384518 hasConcept C1342335 @default.
- W1991384518 hasConcept C175817850 @default.
- W1991384518 hasConcept C30951146 @default.
- W1991384518 hasConcept C54355233 @default.
- W1991384518 hasConcept C54458228 @default.
- W1991384518 hasConcept C64962909 @default.
- W1991384518 hasConcept C66144319 @default.
- W1991384518 hasConcept C67705224 @default.
- W1991384518 hasConcept C70721500 @default.
- W1991384518 hasConcept C76346623 @default.
- W1991384518 hasConcept C86803240 @default.
- W1991384518 hasConcept C94671646 @default.
- W1991384518 hasConceptScore W1991384518C104317684 @default.
- W1991384518 hasConceptScore W1991384518C107745601 @default.