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- W1991385009 abstract "A single oral dose of 2,3,7,7-tetrachlorodibenzo-p-dioxin (TCDD) (20 or 40 μg/kg body wet) administered to rats resulted in reduced body weight gain, water intake, degenerative changes in the liver and involution of the thymus. Although a restricted diet alone caused thymic involutions it was shown that TCDD at 10 or 20 μg/kg body wt accentuated this atrophy. Microscopically, a marked atrophy of the thymus and swelling and necrosis of the liver were found in the malnourished animals. The effects of TCDD were also tested in rats fed either 3.5%, 26% or 55% protein. There was no clear relation between the protein level and the influence of TCDD on the thymus. However, the effect of TCDD on body weight and the liver was more severe in rats given low protein diet. These effects were not reversed by high protein diet. Since it is unlikely that the influence of TCDD on the thymus is related to malnutrition, other mechanisms, such as depletion of energy reserves, a direct effect of TCDD on the thymus ior a mediation by the hepatotoxic action may be involved." @default.
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- W1991385009 date "1981-01-01" @default.
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- W1991385009 title "The influence of malnutrition on the toxicity of 2,3,7,8-tetrachlorodiobenzo-p-dioxin (TCDD) in rats" @default.
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- W1991385009 doi "https://doi.org/10.1016/0300-483x(81)90018-4" @default.
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