FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991387438> ?p ?o ?g. }

• W1991387438 endingPage "126" @default.
• W1991387438 startingPage "117" @default.
• W1991387438 abstract "The present study was undertaken to examine the effects of prenatal nicotine exposure by two different routes of drug administration, injection and infusion, on the development of monoaminergic systems and open field behavior in the neonatal and juvenile rat. The nicotine administration to pregnant Sprague-Dawley rats was carried out by subcutaneous injection (3 mg/kg twice daily) or infusion via implanted osmotic minipumps (6 mg/kg/day) from gestational day 4 (GD4) until GD20. At postnatal day 7 (PD7), 15 and 22, the contents of the neurotransmitters and their metabolites including noradrenaline (NA), dopamine (DA), dihydroxyphenylacetic acid (DOPAC), homovanilic acid (HVA), serotonin (5-HT) and 5-hydroxy-3-indolacetic acid (5-HIAA) were measured in the midbrain+pons - medulla (M + P - M), forebrain and cerebellum. Prenatal nicotine exposure caused a persistent reduction of DA turnover in the forebrain at PD15 and PD22. In addition, the 5-HT system was also affected by prenatal nicotine, and reductions of 5-HT turnover in the M + P - M at PD15 and in the forebrain and the cerebellum at PD22 were found. Although there was no effect of prenatal nicotine on NE contents, the involvement of this system remains uncertain since we measured only NE contents without metabolites. In the present study, we also found significant route-related changes in the contents of the monoamines and metabolites in the NA, DA and 5-HT systems in all brain regions in rat offspring besides the effects of prenatal nicotine. In addition, the difference in administration route reflected the results of the open field test and the number of ambulations in the injection-group was less than that in the infusion-groups with no relation to nicotine administration. Therefore, such effects of prenatal stress accompanied by drug administration are not negligible in considering the risk assessment of prenatal nicotine exposure." @default.
• W1991387438 created "2016-06-24" @default.
• W1991387438 creator A5017723586 @default.
• W1991387438 creator A5018118991 @default.
• W1991387438 creator A5020795958 @default.
• W1991387438 creator A5039750536 @default.
• W1991387438 creator A5042709412 @default.
• W1991387438 creator A5055510024 @default.
• W1991387438 creator A5077846797 @default.
• W1991387438 creator A5082094757 @default.
• W1991387438 creator A5085901390 @default.
• W1991387438 date "1997-08-01" @default.
• W1991387438 modified "2023-09-27" @default.
• W1991387438 title "Prenatal nicotine exposure affects the development of the central serotonergic system as well as the dopaminergic system in rat offspring: involvement of route of drug administrations" @default.
• W1991387438 cites W1589533897 @default.
• W1991387438 cites W1969848260 @default.
• W1991387438 cites W1972470488 @default.
• W1991387438 cites W1973353054 @default.
• W1991387438 cites W1974225403 @default.
• W1991387438 cites W1996514137 @default.
• W1991387438 cites W2015729550 @default.
• W1991387438 cites W2018797451 @default.
• W1991387438 cites W2019688879 @default.
• W1991387438 cites W2025340326 @default.
• W1991387438 cites W2028418809 @default.
• W1991387438 cites W2030955576 @default.
• W1991387438 cites W2031046608 @default.
• W1991387438 cites W2032729792 @default.
• W1991387438 cites W2038571313 @default.
• W1991387438 cites W2038652891 @default.
• W1991387438 cites W2043313965 @default.
• W1991387438 cites W2045849590 @default.
• W1991387438 cites W2047233047 @default.
• W1991387438 cites W2048799794 @default.
• W1991387438 cites W2055221558 @default.
• W1991387438 cites W2062555791 @default.
• W1991387438 cites W2069222301 @default.
• W1991387438 cites W2073039458 @default.
• W1991387438 cites W2074385293 @default.
• W1991387438 cites W2095491217 @default.
• W1991387438 cites W2111581233 @default.
• W1991387438 cites W2137799116 @default.
• W1991387438 cites W2462981569 @default.
• W1991387438 cites W247473604 @default.
• W1991387438 cites W2500472065 @default.
• W1991387438 cites W4256061058 @default.
• W1991387438 cites W93758419 @default.
• W1991387438 doi "https://doi.org/10.1016/s0165-3806(97)00092-8" @default.
• W1991387438 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9298240" @default.
• W1991387438 hasPublicationYear "1997" @default.
• W1991387438 type Work @default.
• W1991387438 sameAs 1991387438 @default.
• W1991387438 citedByCount "119" @default.
• W1991387438 countsByYear W19913874382012 @default.
• W1991387438 countsByYear W19913874382013 @default.
• W1991387438 countsByYear W19913874382014 @default.
• W1991387438 countsByYear W19913874382015 @default.
• W1991387438 countsByYear W19913874382016 @default.
• W1991387438 countsByYear W19913874382017 @default.
• W1991387438 countsByYear W19913874382018 @default.
• W1991387438 countsByYear W19913874382019 @default.
• W1991387438 countsByYear W19913874382020 @default.
• W1991387438 countsByYear W19913874382021 @default.
• W1991387438 countsByYear W19913874382022 @default.
• W1991387438 crossrefType "journal-article" @default.
• W1991387438 hasAuthorship W1991387438A5017723586 @default.
• W1991387438 hasAuthorship W1991387438A5018118991 @default.
• W1991387438 hasAuthorship W1991387438A5020795958 @default.
• W1991387438 hasAuthorship W1991387438A5039750536 @default.
• W1991387438 hasAuthorship W1991387438A5042709412 @default.
• W1991387438 hasAuthorship W1991387438A5055510024 @default.
• W1991387438 hasAuthorship W1991387438A5077846797 @default.
• W1991387438 hasAuthorship W1991387438A5082094757 @default.
• W1991387438 hasAuthorship W1991387438A5085901390 @default.
• W1991387438 hasConcept C112672928 @default.
• W1991387438 hasConcept C126322002 @default.
• W1991387438 hasConcept C134018914 @default.
• W1991387438 hasConcept C137183658 @default.
• W1991387438 hasConcept C170493617 @default.
• W1991387438 hasConcept C187714386 @default.
• W1991387438 hasConcept C2775864247 @default.
• W1991387438 hasConcept C2779234561 @default.
• W1991387438 hasConcept C2779547902 @default.
• W1991387438 hasConcept C2779715522 @default.
• W1991387438 hasConcept C37000724 @default.
• W1991387438 hasConcept C42251903 @default.
• W1991387438 hasConcept C513476851 @default.
• W1991387438 hasConcept C529278444 @default.
• W1991387438 hasConcept C54355233 @default.
• W1991387438 hasConcept C71924100 @default.
• W1991387438 hasConcept C86803240 @default.
• W1991387438 hasConceptScore W1991387438C112672928 @default.
• W1991387438 hasConceptScore W1991387438C126322002 @default.
• W1991387438 hasConceptScore W1991387438C134018914 @default.
• W1991387438 hasConceptScore W1991387438C137183658 @default.
• W1991387438 hasConceptScore W1991387438C170493617 @default.
• W1991387438 hasConceptScore W1991387438C187714386 @default.
• W1991387438 hasConceptScore W1991387438C2775864247 @default.

• next