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- W1991387753 abstract "The effects of SR-A I/II deficiency and a synthetic anti-oxidant BO-653 on a diet-induced atherosclerosis in C57BL/6J, an inbred strain known to be susceptible to diet-induced atherosclerotic lesion formation, were examined. Quantitative analysis of the extent of atherosclerotic lesions in the mice fed the high-fat diet revealed that the atherosclerotic lesion area in SR-A I/II mutants was significantly reduced by 70% compared to wild type mice. A similar level of lesion reduction (75%) was found in wild type mice fed the high-fat diet supplemented with 0.6% BO-653 compared to those without BO-653. Thus, for C57BL/6J in the setting of prolonged exposure to a high-fat diet, defect of SR-A I/II expression is significantly protective against the development of atherosclerosis, as is the synthetic anti-oxidant BO-653. These results indicate that SR-A I/II has a crucial role in atherosclerotic lesion formation with uptake of oxidized-LDL in this mouse model." @default.
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- W1991387753 date "2001-01-01" @default.
- W1991387753 modified "2023-10-18" @default.
- W1991387753 title "Macrophage Scavenger Receptor (SR-A I/II) Deficiency Reduced Diet-induced Atherosclerosis in C57BL/6J Mice" @default.
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- W1991387753 doi "https://doi.org/10.5551/jat1994.8.1" @default.
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