FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991388685> ?p ?o ?g. }

• W1991388685 endingPage "1486" @default.
• W1991388685 startingPage "1476" @default.
• W1991388685 abstract "This study sought to test the hypothesis that pressure stress of the adenylyl cyclase 6-deleted (AC6-KO) heart would result in excessive hypertrophy, early dilation and dysfunction, and increased fibrosis. Cardiac-directed AC6 expression attenuates left ventricular (LV) hypertrophy and dysfunction in cardiomyopathy. AC6-KO and control (CON) mice underwent transverse aortic constriction (TAC) to induce pressure overload. Measures of LV hypertrophy, function, and fibrosis were obtained 3 weeks after TAC, and LV samples were assessed for alterations in expression of FHL1 and periostin. Three weeks after TAC, female AC6-KO mice had preserved left ventricular (LV) ejection fraction (CON: 22 ± 2%; AC6-KO: 52 ± 4%; p < 0.001) and reduced LV end-diastolic dimension (CON: 4.6 ± 0.1 mm; AC6-KO: 3.6 ± 0.1 mm; p < 0.001). Reduced LV/tibial length ratio (CON: 10.4 ± 1.5 mg/mm; AC6-KO: 7.5 ± 2.3 mg/mm; p < 0.001) and reduced LV expression of atrial natriuretic factor (p < 0.05), α-skeletal muscle actin (p < 0.05), and beta-myosin heavy chain (p < 0.05) were observed in AC6-KO mice. In addition, AC6 deletion was associated with less LV fibrosis (p < 0.01) and reduced collagen types I (p < 0.05) and III (p < 0.05) expression 3 weeks after TAC. LV protein expression of FHL1 (p < 0.02) and periostin (p = 0.04) were reduced after TAC in AC6-KO mice. The roles of AC6 deletion in cardiac myocytes and fibroblasts were examined in vitro using pharmacological hypertrophy and AC6 knockdown (small interfering ribonucleic acid), which recapitulated in vivo findings. The deleterious effects of LV pressure overload were reduced in female mice with AC6 deletion. Reductions in FHL1 and periostin expression, direct consequences of reduced AC6 in cardiac myocytes and fibroblasts, appear to be of mechanistic importance for these unanticipated beneficial effects." @default.
• W1991388685 created "2016-06-24" @default.
• W1991388685 creator A5006792323 @default.
• W1991388685 creator A5011147985 @default.
• W1991388685 creator A5034957704 @default.
• W1991388685 creator A5051781429 @default.
• W1991388685 creator A5073721957 @default.
• W1991388685 creator A5083905221 @default.
• W1991388685 creator A5088016802 @default.
• W1991388685 date "2010-04-01" @default.
• W1991388685 modified "2023-09-29" @default.
• W1991388685 title "Adenylyl Cyclase 6 Deletion Reduces Left Ventricular Hypertrophy, Dilation, Dysfunction, and Fibrosis in Pressure-Overloaded Female Mice" @default.
• W1991388685 cites W1979344355 @default.
• W1991388685 cites W2001762954 @default.
• W1991388685 cites W2035371717 @default.
• W1991388685 cites W2046846631 @default.
• W1991388685 cites W2049605980 @default.
• W1991388685 cites W2057490727 @default.
• W1991388685 cites W2063638570 @default.
• W1991388685 cites W2087706354 @default.
• W1991388685 cites W2088452765 @default.
• W1991388685 cites W2099757528 @default.
• W1991388685 cites W2102140472 @default.
• W1991388685 cites W2105849179 @default.
• W1991388685 cites W2106165503 @default.
• W1991388685 cites W2107190331 @default.
• W1991388685 cites W2108477432 @default.
• W1991388685 cites W2112720988 @default.
• W1991388685 cites W2114898591 @default.
• W1991388685 cites W2138403535 @default.
• W1991388685 cites W2150676239 @default.
• W1991388685 cites W2156702425 @default.
• W1991388685 cites W2157506278 @default.
• W1991388685 doi "https://doi.org/10.1016/j.jacc.2009.11.066" @default.
• W1991388685 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3081694" @default.
• W1991388685 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20359598" @default.
• W1991388685 hasPublicationYear "2010" @default.
• W1991388685 type Work @default.
• W1991388685 sameAs 1991388685 @default.
• W1991388685 citedByCount "31" @default.
• W1991388685 countsByYear W19913886852012 @default.
• W1991388685 countsByYear W19913886852013 @default.
• W1991388685 countsByYear W19913886852014 @default.
• W1991388685 countsByYear W19913886852015 @default.
• W1991388685 countsByYear W19913886852016 @default.
• W1991388685 countsByYear W19913886852017 @default.
• W1991388685 countsByYear W19913886852018 @default.
• W1991388685 countsByYear W19913886852019 @default.
• W1991388685 countsByYear W19913886852020 @default.
• W1991388685 countsByYear W19913886852021 @default.
• W1991388685 countsByYear W19913886852022 @default.
• W1991388685 crossrefType "journal-article" @default.
• W1991388685 hasAuthorship W1991388685A5006792323 @default.
• W1991388685 hasAuthorship W1991388685A5011147985 @default.
• W1991388685 hasAuthorship W1991388685A5034957704 @default.
• W1991388685 hasAuthorship W1991388685A5051781429 @default.
• W1991388685 hasAuthorship W1991388685A5073721957 @default.
• W1991388685 hasAuthorship W1991388685A5083905221 @default.
• W1991388685 hasAuthorship W1991388685A5088016802 @default.
• W1991388685 hasBestOaLocation W19913886851 @default.
• W1991388685 hasConcept C126322002 @default.
• W1991388685 hasConcept C134018914 @default.
• W1991388685 hasConcept C164705383 @default.
• W1991388685 hasConcept C167414201 @default.
• W1991388685 hasConcept C189165786 @default.
• W1991388685 hasConcept C2777699602 @default.
• W1991388685 hasConcept C2778198053 @default.
• W1991388685 hasConcept C2778271984 @default.
• W1991388685 hasConcept C2780559512 @default.
• W1991388685 hasConcept C3018763269 @default.
• W1991388685 hasConcept C3018791406 @default.
• W1991388685 hasConcept C71924100 @default.
• W1991388685 hasConcept C78085059 @default.
• W1991388685 hasConcept C86803240 @default.
• W1991388685 hasConcept C95444343 @default.
• W1991388685 hasConceptScore W1991388685C126322002 @default.
• W1991388685 hasConceptScore W1991388685C134018914 @default.
• W1991388685 hasConceptScore W1991388685C164705383 @default.
• W1991388685 hasConceptScore W1991388685C167414201 @default.
• W1991388685 hasConceptScore W1991388685C189165786 @default.
• W1991388685 hasConceptScore W1991388685C2777699602 @default.
• W1991388685 hasConceptScore W1991388685C2778198053 @default.
• W1991388685 hasConceptScore W1991388685C2778271984 @default.
• W1991388685 hasConceptScore W1991388685C2780559512 @default.
• W1991388685 hasConceptScore W1991388685C3018763269 @default.
• W1991388685 hasConceptScore W1991388685C3018791406 @default.
• W1991388685 hasConceptScore W1991388685C71924100 @default.
• W1991388685 hasConceptScore W1991388685C78085059 @default.
• W1991388685 hasConceptScore W1991388685C86803240 @default.
• W1991388685 hasConceptScore W1991388685C95444343 @default.
• W1991388685 hasIssue "14" @default.
• W1991388685 hasLocation W19913886851 @default.
• W1991388685 hasLocation W19913886852 @default.
• W1991388685 hasLocation W19913886853 @default.
• W1991388685 hasLocation W19913886854 @default.
• W1991388685 hasOpenAccess W1991388685 @default.
• W1991388685 hasPrimaryLocation W19913886851 @default.
• W1991388685 hasRelatedWork W1660427814 @default.

• next