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• W1991397356 abstract "Objectives . Early change in rheumatoid arthritis (RA) is characterised by periarticular osteopenia. We investigated the relationship of early metacarpal digital X-ray radiogrammetry bone mineral density (DXR-BMD) change rate (RC-BMD, mg/cm 2 /month) to longitudinal changes in hand and feet radiographic and wrist MRI scores over 1 year. Materials and Methods . 10 RA patients completed the study and had wrist 3T-MRI and hand and feet X-rays at various time points over 1 year. MRI was scored by RAMRIS, X-ray was done by van der Heijde modified Sharp scoring, and RC-BMD was analysed using dxr-online. Results . There was good correlation amongst the two scorers for MRI measures and ICC for erosions: 0.984, BME: 0.943, and synovitis: 0.657. Strong relationships were observed between RC-BMD at 12-week and 1-year change in wrist marrow oedema (BME) (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mi>r</mml:mi><mml:mo>=</mml:mo><mml:mn>0.78</mml:mn></mml:math>, <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.035</mml:mn></mml:math>) but not with erosion, synovitis, or radiographic scores. Conclusion . Early RC-BMD correlates with 1-year wrist BME change, which is a known predictor of future erosion and joint damage. However, in our pilot study, early RC-BMD did not show relationships to MRI erosion or radiographic changes over 1 year. This may reflect a slower kinetic in the appearance of MRI/radiographic erosions, generating the hypothesis that RC-BMD may be a more sensitive and early structural prognostic marker in RA follow-up." @default.
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• W1991397356 date "2015-02-17" @default.
• W1991397356 modified "2023-10-15" @default.
• W1991397356 title "Early Metacarpal Bone Mineral Density Loss Using Digital X-Ray Radiogrammetry and 3-Tesla Wrist MRI in Established Rheumatoid Arthritis: A Longitudinal One-Year Observational Study" @default.
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• W1991397356 doi "https://doi.org/10.1155/2015/852989" @default.
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