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- W1991407027 abstract "In the past decade, Caenorhabditis elegans has been used to dissect several genetic pathways involved in immunity; however, little is known about transcription factors that regulate the expression of immune effectors. C. elegans does not appear to have a functional homolog of the key immune transcription factor NF-kappaB. Here we show that that the intestinal GATA transcription factor ELT-2 is required for both immunity to Salmonella enterica and expression of a C-type lectin gene, clec-67, which is expressed in the intestinal cells and is a good marker of S. enterica infection. We also found that ELT-2 is required for immunity to Pseudomonas aeruginosa, Enterococcus faecalis, and Cryptococcus neoformans. Lack of immune inhibition by DAF-2, which negatively regulates the FOXO transcription factor DAF-16, rescues the hypersusceptibility to pathogens phenotype of elt-2(RNAi) animals. Our results indicate that ELT-2 is part of a multi-pathogen defense pathway that regulates innate immunity independently of the DAF-2/DAF-16 signaling pathway." @default.
- W1991407027 created "2016-06-24" @default.
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- W1991407027 date "2006-12-20" @default.
- W1991407027 modified "2023-10-11" @default.
- W1991407027 title "GATA Transcription Factor Required for Immunity to Bacterial and Fungal Pathogens" @default.
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- W1991407027 doi "https://doi.org/10.1371/journal.pone.0000077" @default.
- W1991407027 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1762309" @default.
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