Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991408517> ?p ?o ?g. }
- W1991408517 endingPage "613" @default.
- W1991408517 startingPage "601" @default.
- W1991408517 abstract "The disassembly of cilia and flagella is linked to the cell cycle and environmental cues. We have found that ubiquitination of flagellar proteins is an integral part of flagellar disassembly. Free ubiquitin and the ubiquitin-conjugating enzyme CrUbc13 are detected in flagella, and several proteins are ubiquitinated in isolated flagella when exogenous ubiquitin and adenosine triphosphatase are added, suggesting that the ubiquitin conjugation system operates in flagella. Levels of ubiquitinated flagellar proteins increase during flagellar resorption, especially in intraflagellar transport (IFT) mutants, suggesting that disassembly products are labeled with ubiquitin and transported to the cell body by IFT. Substrates of the ubiquitin conjugation system include α-tubulin (but not β-tubulin), a dynein subunit (IC2), two signaling proteins involved in the mating process, cyclic guanosine monophosphate–dependent kinase, and the cation channel polycystic kidney disease 2. Ubiquitination of flagellar proteins is enhanced early in mating, suggesting that ubiquitination also plays an active role in regulating signaling pathways in flagella." @default.
- W1991408517 created "2016-06-24" @default.
- W1991408517 creator A5011658772 @default.
- W1991408517 creator A5036397909 @default.
- W1991408517 creator A5074245341 @default.
- W1991408517 date "2009-08-24" @default.
- W1991408517 modified "2023-10-15" @default.
- W1991408517 title "The ubiquitin conjugation system is involved in the disassembly of cilia and flagella" @default.
- W1991408517 cites W1490806999 @default.
- W1991408517 cites W1527289043 @default.
- W1991408517 cites W1583761679 @default.
- W1991408517 cites W1586177028 @default.
- W1991408517 cites W1793231479 @default.
- W1991408517 cites W1963825895 @default.
- W1991408517 cites W1963967499 @default.
- W1991408517 cites W1970252376 @default.
- W1991408517 cites W1971060771 @default.
- W1991408517 cites W1971575429 @default.
- W1991408517 cites W1971961888 @default.
- W1991408517 cites W1974601240 @default.
- W1991408517 cites W1988617344 @default.
- W1991408517 cites W1988632377 @default.
- W1991408517 cites W1993880917 @default.
- W1991408517 cites W1995953017 @default.
- W1991408517 cites W1998837332 @default.
- W1991408517 cites W2000301861 @default.
- W1991408517 cites W2001536138 @default.
- W1991408517 cites W2001949416 @default.
- W1991408517 cites W2006399184 @default.
- W1991408517 cites W2008185369 @default.
- W1991408517 cites W2009001010 @default.
- W1991408517 cites W2011696737 @default.
- W1991408517 cites W2017569893 @default.
- W1991408517 cites W2020738975 @default.
- W1991408517 cites W2025963872 @default.
- W1991408517 cites W2030939638 @default.
- W1991408517 cites W2033799985 @default.
- W1991408517 cites W2044496115 @default.
- W1991408517 cites W2045083882 @default.
- W1991408517 cites W2047596417 @default.
- W1991408517 cites W2052203674 @default.
- W1991408517 cites W2054131393 @default.
- W1991408517 cites W2054221206 @default.
- W1991408517 cites W2054938702 @default.
- W1991408517 cites W2062584366 @default.
- W1991408517 cites W2064925044 @default.
- W1991408517 cites W2065337493 @default.
- W1991408517 cites W2072902301 @default.
- W1991408517 cites W2079171495 @default.
- W1991408517 cites W2083147072 @default.
- W1991408517 cites W2083516848 @default.
- W1991408517 cites W2087920918 @default.
- W1991408517 cites W2087923101 @default.
- W1991408517 cites W2090068859 @default.
- W1991408517 cites W2093676487 @default.
- W1991408517 cites W2097214606 @default.
- W1991408517 cites W2102753929 @default.
- W1991408517 cites W2103036283 @default.
- W1991408517 cites W2109123964 @default.
- W1991408517 cites W2109995563 @default.
- W1991408517 cites W2114413959 @default.
- W1991408517 cites W2116079099 @default.
- W1991408517 cites W2117609300 @default.
- W1991408517 cites W2119188697 @default.
- W1991408517 cites W2119509468 @default.
- W1991408517 cites W2120858746 @default.
- W1991408517 cites W2121781216 @default.
- W1991408517 cites W2128841783 @default.
- W1991408517 cites W2133817119 @default.
- W1991408517 cites W2141459857 @default.
- W1991408517 cites W2145300367 @default.
- W1991408517 cites W2146151168 @default.
- W1991408517 cites W2148022231 @default.
- W1991408517 cites W2148151206 @default.
- W1991408517 cites W2159407840 @default.
- W1991408517 cites W2160266887 @default.
- W1991408517 cites W2161216917 @default.
- W1991408517 cites W2166172589 @default.
- W1991408517 cites W2166977115 @default.
- W1991408517 cites W2168056473 @default.
- W1991408517 cites W2170339840 @default.
- W1991408517 cites W4211143281 @default.
- W1991408517 cites W4242851385 @default.
- W1991408517 doi "https://doi.org/10.1083/jcb.200903066" @default.
- W1991408517 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2733750" @default.
- W1991408517 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19704024" @default.
- W1991408517 hasPublicationYear "2009" @default.
- W1991408517 type Work @default.
- W1991408517 sameAs 1991408517 @default.
- W1991408517 citedByCount "99" @default.
- W1991408517 countsByYear W19914085172012 @default.
- W1991408517 countsByYear W19914085172013 @default.
- W1991408517 countsByYear W19914085172014 @default.
- W1991408517 countsByYear W19914085172015 @default.
- W1991408517 countsByYear W19914085172016 @default.
- W1991408517 countsByYear W19914085172017 @default.
- W1991408517 countsByYear W19914085172018 @default.
- W1991408517 countsByYear W19914085172019 @default.