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- W1991409866 abstract "Primary biliary cirrhosis (PBC) is a chronic and progressive cholestatic liver disease of unknown etiopathogenesis that mainly affects middle-aged women. Patients show non-suppurative cholangitis with damage and destruction of the small- and medium-sized intrahepatic bile ducts. Characteristically, the disease is strongly associated with autoimmune phenomena such as the appearance of serum antimitochondrial autoantibodies (AMA) and portal infiltrating T cells against the inner lipoyl domain in the E2 component of the pyruvate dehydrogenase complex (PDC-E2). Here we review the major characteristics of a series of inducible and genetically modified animal models of PBC and analyze the similarities and differences to PBC features in humans." @default.
- W1991409866 created "2016-06-24" @default.
- W1991409866 creator A5011832388 @default.
- W1991409866 creator A5075950171 @default.
- W1991409866 date "2012-02-01" @default.
- W1991409866 modified "2023-10-18" @default.
- W1991409866 title "Approaches to the pathogenesis of primary biliary cirrhosis through animal models" @default.
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- W1991409866 doi "https://doi.org/10.1016/j.clinre.2011.07.007" @default.
- W1991409866 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21862437" @default.
- W1991409866 hasPublicationYear "2012" @default.
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