Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991410119> ?p ?o ?g. }
- W1991410119 endingPage "211" @default.
- W1991410119 startingPage "189" @default.
- W1991410119 abstract "Three classes of organometallic complexes, metallocene diacidos Cp2MX2(M=Ti, V, Nb, Mo, Re), ferricenium salts and organotin compounds have been reported to exhibit impressive in vivo or in vitro antitumour activities against a range of tumour cell lines. Titanocene dichloride is currently on the phase II clinical trials. Biological studies suggest that DNA is one of the primary intracellular targets of the metallocene dihalides but their mechanism of action is poorly understood. By using various modern techniques, the binding modes of Cp2TiCl2, Cp2VCl2, Cp2NbCl2, Cp2MoCl2, Cp2ZrCl2, Cp2Fe+X−, (CH3)2SnCl2, (C2H5)2SnCl2, (C2H5)2SnCl2(phen) with DNA and nucleotides in aqueous solution have been investigated. The results show that all the above organometallic agents exhibit high affinity to phosphate group of nucleotides. In aqueous solution, 5′GMP(or 5′dGMP), 5′AMP, 5′CMP, 5′TMP with Cp2TiCl2 or Cp2MoCl2 form chelate complexes in which both base nitrogen atom and phosphate oxygen atom of nucleotides bind to the metal center; whereas the other organometallics may bind to dGMP via only the phosphate group. The interactions between Cp2TiCl2, Cp2ZrCl2, (CH3)2SnCl2 or (C2H5)2SnCl2 with calf thymus DNA suggest that Cp2TiCl2(aq) may bind to both the base ring sites and the phosphate backbone of DNA; while other organometallics(aq) bind to DNA via only the phosphate group. In addition, the relationship between DNA binding property of metal anticancer complex and their anticancer activity is discussed and a hypothesis named ‘Two-Pole Complementary Principle’ is also put forward and some criteria are suggested as well." @default.
- W1991410119 created "2016-06-24" @default.
- W1991410119 creator A5020451831 @default.
- W1991410119 creator A5059644813 @default.
- W1991410119 date "1999-05-01" @default.
- W1991410119 modified "2023-10-16" @default.
- W1991410119 title "Interactions of organometallic anticancer agents with nucleotides and DNA" @default.
- W1991410119 cites W133791675 @default.
- W1991410119 cites W133898051 @default.
- W1991410119 cites W1550263632 @default.
- W1991410119 cites W1556983269 @default.
- W1991410119 cites W1590106897 @default.
- W1991410119 cites W16564454 @default.
- W1991410119 cites W1732688205 @default.
- W1991410119 cites W1963605679 @default.
- W1991410119 cites W1969608306 @default.
- W1991410119 cites W1969722215 @default.
- W1991410119 cites W1972528047 @default.
- W1991410119 cites W1972798283 @default.
- W1991410119 cites W1973184519 @default.
- W1991410119 cites W1973260055 @default.
- W1991410119 cites W1973591492 @default.
- W1991410119 cites W1973753872 @default.
- W1991410119 cites W1974075450 @default.
- W1991410119 cites W1976948242 @default.
- W1991410119 cites W1981361641 @default.
- W1991410119 cites W1981519760 @default.
- W1991410119 cites W1982615079 @default.
- W1991410119 cites W1986198240 @default.
- W1991410119 cites W1991565868 @default.
- W1991410119 cites W1992673178 @default.
- W1991410119 cites W1992752721 @default.
- W1991410119 cites W1992817313 @default.
- W1991410119 cites W1992886533 @default.
- W1991410119 cites W1996417256 @default.
- W1991410119 cites W2003706534 @default.
- W1991410119 cites W2004243354 @default.
- W1991410119 cites W2005146936 @default.
- W1991410119 cites W2005322310 @default.
- W1991410119 cites W2005722327 @default.
- W1991410119 cites W2014720477 @default.
- W1991410119 cites W2015694743 @default.
- W1991410119 cites W2016583285 @default.
- W1991410119 cites W2018855360 @default.
- W1991410119 cites W2018878306 @default.
- W1991410119 cites W2020514964 @default.
- W1991410119 cites W2027202657 @default.
- W1991410119 cites W2031821950 @default.
- W1991410119 cites W2033020769 @default.
- W1991410119 cites W2033210527 @default.
- W1991410119 cites W2033293073 @default.
- W1991410119 cites W2039241659 @default.
- W1991410119 cites W2039276528 @default.
- W1991410119 cites W2040529066 @default.
- W1991410119 cites W2040570730 @default.
- W1991410119 cites W2041218175 @default.
- W1991410119 cites W2041363678 @default.
- W1991410119 cites W2041770648 @default.
- W1991410119 cites W2042726692 @default.
- W1991410119 cites W2052597254 @default.
- W1991410119 cites W2053088222 @default.
- W1991410119 cites W2057996887 @default.
- W1991410119 cites W2059128931 @default.
- W1991410119 cites W2060553534 @default.
- W1991410119 cites W2060971747 @default.
- W1991410119 cites W2064838296 @default.
- W1991410119 cites W2065539197 @default.
- W1991410119 cites W2068989603 @default.
- W1991410119 cites W2073005147 @default.
- W1991410119 cites W2073018467 @default.
- W1991410119 cites W2078118681 @default.
- W1991410119 cites W2079539223 @default.
- W1991410119 cites W2079984318 @default.
- W1991410119 cites W2083433470 @default.
- W1991410119 cites W2085450304 @default.
- W1991410119 cites W2089102220 @default.
- W1991410119 cites W2091181078 @default.
- W1991410119 cites W2094354608 @default.
- W1991410119 cites W2094566836 @default.
- W1991410119 cites W2101662057 @default.
- W1991410119 cites W2105686863 @default.
- W1991410119 cites W2107509757 @default.
- W1991410119 cites W2122641440 @default.
- W1991410119 cites W2148302976 @default.
- W1991410119 cites W2154228453 @default.
- W1991410119 cites W2156785036 @default.
- W1991410119 cites W2163820386 @default.
- W1991410119 cites W2183791595 @default.
- W1991410119 cites W2288093942 @default.
- W1991410119 cites W2341158548 @default.
- W1991410119 cites W2395700648 @default.
- W1991410119 cites W2437946319 @default.
- W1991410119 cites W293747239 @default.
- W1991410119 cites W2943284274 @default.
- W1991410119 cites W2949845980 @default.
- W1991410119 cites W2951640222 @default.
- W1991410119 cites W3004576110 @default.
- W1991410119 cites W3004754575 @default.