FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991410130> ?p ?o ?g. }

• W1991410130 endingPage "273" @default.
• W1991410130 startingPage "265" @default.
• W1991410130 abstract "Repeated administration of the GABA(A) receptor antagonist bicuculline methiodide into the basolateral nucleus of the amygdala at doses subthreshold to eliciting a full response will eventually produce long-term 'priming', such that heart rate, blood pressure as well as anxiety are increased at the lower doses. The present study was conducted in order to determine if the long-term priming of anxiety within the basolateral nucleus is producing a condition similar to that seen in human panic disorder by testing the response elicited by i.v. lactate infusions, since lactate infusions induce a panic attack in patients with panic disorder. Male Wistar rats were fitted with femoral arterial and venous catheters and chronic microinjection cannulae into the basolateral nucleus. Repeated daily injections of a subthreshold dose of bicuculline methiodide into the basolateral nucleus for 4-5 days elicited a primed response, while the same procedure with artificial cerebrospinal fluid vehicle (a-CSF; sham-primed) had no effect. Following priming, rats received both sodium lactate infusions (0.5 N, 10 ml/kg) or 0.9% saline in a random order separated by 48 h. Heart rate and blood pressure were monitored throughout the infusion and the animals were immediately placed in the social interaction test to assess their anxiety response. Only primed and not sham-primed rats responded to a lactate infusion with significant increases in heart rate, blood pressure and experimental anxiety. Thus, rats which are primed with chronic subthreshold GABA receptor blockade in the basolateral nucleus develop a sensitivity to sodium lactate, similar to human panic disorder patients." @default.
• W1991410130 created "2016-06-24" @default.
• W1991410130 creator A5003938450 @default.
• W1991410130 creator A5089740179 @default.
• W1991410130 date "2000-04-01" @default.
• W1991410130 modified "2023-10-16" @default.
• W1991410130 title "Sodium lactate elicits anxiety in rats after repeated GABA receptor blockade in the basolateral amygdala" @default.
• W1991410130 cites W1480042661 @default.
• W1991410130 cites W1524346434 @default.
• W1991410130 cites W156306960 @default.
• W1991410130 cites W1601515225 @default.
• W1991410130 cites W1633341882 @default.
• W1991410130 cites W1801330609 @default.
• W1991410130 cites W1961384091 @default.
• W1991410130 cites W1965313832 @default.
• W1991410130 cites W1971397158 @default.
• W1991410130 cites W1984732473 @default.
• W1991410130 cites W1989691108 @default.
• W1991410130 cites W1992875076 @default.
• W1991410130 cites W2004224352 @default.
• W1991410130 cites W2008126685 @default.
• W1991410130 cites W2008416369 @default.
• W1991410130 cites W2009140566 @default.
• W1991410130 cites W2016373320 @default.
• W1991410130 cites W2019663609 @default.
• W1991410130 cites W2019884656 @default.
• W1991410130 cites W2023431571 @default.
• W1991410130 cites W2029569556 @default.
• W1991410130 cites W2029701168 @default.
• W1991410130 cites W2029985373 @default.
• W1991410130 cites W2030191470 @default.
• W1991410130 cites W2039300800 @default.
• W1991410130 cites W2041118507 @default.
• W1991410130 cites W2052320768 @default.
• W1991410130 cites W2052788217 @default.
• W1991410130 cites W2059354993 @default.
• W1991410130 cites W2061228427 @default.
• W1991410130 cites W2066456122 @default.
• W1991410130 cites W2066686316 @default.
• W1991410130 cites W2068362233 @default.
• W1991410130 cites W2077711014 @default.
• W1991410130 cites W2089304680 @default.
• W1991410130 cites W2103140876 @default.
• W1991410130 cites W2123717940 @default.
• W1991410130 cites W2169230464 @default.
• W1991410130 cites W2337852520 @default.
• W1991410130 cites W2398250261 @default.
• W1991410130 cites W2402166690 @default.
• W1991410130 cites W4232755968 @default.
• W1991410130 cites W4246802087 @default.
• W1991410130 doi "https://doi.org/10.1016/s0014-2999(00)00128-x" @default.
• W1991410130 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10771292" @default.
• W1991410130 hasPublicationYear "2000" @default.
• W1991410130 type Work @default.
• W1991410130 sameAs 1991410130 @default.
• W1991410130 citedByCount "58" @default.
• W1991410130 countsByYear W19914101302012 @default.
• W1991410130 countsByYear W19914101302013 @default.
• W1991410130 countsByYear W19914101302014 @default.
• W1991410130 countsByYear W19914101302015 @default.
• W1991410130 countsByYear W19914101302016 @default.
• W1991410130 countsByYear W19914101302017 @default.
• W1991410130 countsByYear W19914101302018 @default.
• W1991410130 countsByYear W19914101302019 @default.
• W1991410130 countsByYear W19914101302020 @default.
• W1991410130 countsByYear W19914101302021 @default.
• W1991410130 countsByYear W19914101302022 @default.
• W1991410130 crossrefType "journal-article" @default.
• W1991410130 hasAuthorship W1991410130A5003938450 @default.
• W1991410130 hasAuthorship W1991410130A5089740179 @default.
• W1991410130 hasConcept C126322002 @default.
• W1991410130 hasConcept C134018914 @default.
• W1991410130 hasConcept C168258287 @default.
• W1991410130 hasConcept C170493617 @default.
• W1991410130 hasConcept C2777953023 @default.
• W1991410130 hasConcept C2779144063 @default.
• W1991410130 hasConcept C2780451725 @default.
• W1991410130 hasConcept C2780763569 @default.
• W1991410130 hasConcept C42219234 @default.
• W1991410130 hasConcept C71924100 @default.
• W1991410130 hasConcept C84393581 @default.
• W1991410130 hasConceptScore W1991410130C126322002 @default.
• W1991410130 hasConceptScore W1991410130C134018914 @default.
• W1991410130 hasConceptScore W1991410130C168258287 @default.
• W1991410130 hasConceptScore W1991410130C170493617 @default.
• W1991410130 hasConceptScore W1991410130C2777953023 @default.
• W1991410130 hasConceptScore W1991410130C2779144063 @default.
• W1991410130 hasConceptScore W1991410130C2780451725 @default.
• W1991410130 hasConceptScore W1991410130C2780763569 @default.
• W1991410130 hasConceptScore W1991410130C42219234 @default.
• W1991410130 hasConceptScore W1991410130C71924100 @default.
• W1991410130 hasConceptScore W1991410130C84393581 @default.
• W1991410130 hasIssue "2-3" @default.
• W1991410130 hasLocation W19914101301 @default.
• W1991410130 hasLocation W19914101302 @default.
• W1991410130 hasOpenAccess W1991410130 @default.
• W1991410130 hasPrimaryLocation W19914101301 @default.
• W1991410130 hasRelatedWork W1996832665 @default.

• next