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• W1991412552 abstract "No AccessJournal of UrologyInvestigative urology1 Aug 2006The Effect of FK1706 on Erectile Function Following Bilateral Cavernous Nerve Crush Injury in a Rat Modelis companion ofBrain Processing of Audiovisual Sexual Stimuli Inducing Penile Erection: A Positron Emission Tomography Study Narihiko Hayashi, Thomas X. Minor, Rafael Carrion, Raymond Price, Lora Nunes, and Tom F. Lue Narihiko HayashiNarihiko Hayashi Knuppe Molecular Urology Laboratory, Department of Urology, University of California-San Francisco, San Francisco, California More articles by this author , Thomas X. MinorThomas X. Minor Knuppe Molecular Urology Laboratory, Department of Urology, University of California-San Francisco, San Francisco, California More articles by this author , Rafael CarrionRafael Carrion Knuppe Molecular Urology Laboratory, Department of Urology, University of California-San Francisco, San Francisco, California Financial interest and/or other relationship with Pfizer. More articles by this author , Raymond PriceRaymond Price Pharmacology Research Laboratory, Astellas Pharmaceuticals, Inc., Ibaraki, Japan Financial interest and/or other relationship with Astellas. More articles by this author , Lora NunesLora Nunes Knuppe Molecular Urology Laboratory, Department of Urology, University of California-San Francisco, San Francisco, California More articles by this author , and Tom F. LueTom F. Lue Knuppe Molecular Urology Laboratory, Department of Urology, University of California-San Francisco, San Francisco, California Financial interest and/or other relationship with Genix, Pfizer, Lilly-ICOS, Riant, Astellas, Biopharm and Bayer. More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2006.03.071AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We investigated the neurotrophic effect of FK1706 on erectile recovery following bilateral cavernous nerve crush injury in a rat model. Materials and Methods: A total of 28 male Sprague-Dawley rats were randomly divided into 4 equal groups. Seven animals underwent sham operation and subcutaneous vehicle injection, whereas 21 underwent bilateral cavernous nerve crush injury followed by vehicle injection alone, or by low (0.1 mg/kg) or high (1.0 mg/kg) dose FK1706 treatment. Injections were continued 5 days weekly for 8 weeks. Erectile function was then assessed by cavernous nerve electrostimulation and penile tissue was evaluated immunohistochemically. Results: No erectile dysfunction was identified in the sham treated group (mean maximal intracavernous pressure ± SEM 106.8 ± 6.4 cm H2O), whereas nerve injury significantly decreased ICP to 17.9 ± 7.0 cm H2O. FK1706 facilitated neural and erectile recovery in a concentration dependent manner with a mean ICP in the high dose FK treatment group of 80.1 ± 7.8 cm H2O compared with 44.1 ± 12.9 cm H2O in the low dose group. Similar stepwise findings were observed using mean area under the curve data. Sham treated animals showed regular axon sizes and shapes with homogenous GAP-43 and neurofilament staining, whereas injured axons showed irregular shapes, sizes and staining patterns. FK1706 treatment restored axon shape and staining patterns. Injury significantly decreased nicotinamide adenine dinucleotide phosphate staining and FK1706 treatment showed a nonsignificant trend toward increased staining. Conclusions: Bilateral cavernous nerve crush causes reproducible erectile dysfunction, consistent with prior experiments. High dose subcutaneous FK1706 therapy promotes significant neuroregeneration and erectile function recovery. References 1 : Neurologic erectile dysfunction. Urol Clin North Am2001; 28: 289. Google Scholar 2 : Growth factor therapy and neuronal nitric oxide synthase. Int J Impot Res2004; 16: S38. Google Scholar 3 : Radical prostatectomy and cystoprostatectomy with preservation of potency. Results using a new nerve-sparing technique. Br J Urol1984; 56: 694. Google Scholar 4 : Anatomy of cavernous nerves distal to prostate: microdissection study in adult male cadavers. Urology1993; 42: 145. Google Scholar 5 : Urinary and sexual function after radical prostatectomy for clinically localized prostate cancer: the Prostate Cancer Outcomes Study. JAMA2000; 283: 354. 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Google Scholar 18 : Neuroimmunophilins: a novel drug therapy for the reversal of neurodegenerative disease?. Neuroscience2004; 128: 1. Google Scholar 19 : The immunophilin ligand GPI-1046 does not have neuroregenerative effects in MPTP-treated monkeys. Exp Neurol2002; 178: 236. Google Scholar © 2006 by American Urological AssociationFiguresReferencesRelatedDetailsRelated articlesJournal of Urology9 Nov 2018Brain Processing of Audiovisual Sexual Stimuli Inducing Penile Erection: A Positron Emission Tomography Study Volume 176Issue 2August 2006Page: 824-829 Advertisement Copyright & Permissions© 2006 by American Urological AssociationKeywordsratsFK1706woundsSprague-DawleyimpotencepenisnonpenetratingMetricsAuthor Information Narihiko Hayashi Knuppe Molecular Urology Laboratory, Department of Urology, University of California-San Francisco, San Francisco, California More articles by this author Thomas X. Minor Knuppe Molecular Urology Laboratory, Department of Urology, University of California-San Francisco, San Francisco, California More articles by this author Rafael Carrion Knuppe Molecular Urology Laboratory, Department of Urology, University of California-San Francisco, San Francisco, California Financial interest and/or other relationship with Pfizer. More articles by this author Raymond Price Pharmacology Research Laboratory, Astellas Pharmaceuticals, Inc., Ibaraki, Japan Financial interest and/or other relationship with Astellas. More articles by this author Lora Nunes Knuppe Molecular Urology Laboratory, Department of Urology, University of California-San Francisco, San Francisco, California More articles by this author Tom F. Lue Knuppe Molecular Urology Laboratory, Department of Urology, University of California-San Francisco, San Francisco, California Financial interest and/or other relationship with Genix, Pfizer, Lilly-ICOS, Riant, Astellas, Biopharm and Bayer. 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