Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991414575> ?p ?o ?g. }
- W1991414575 endingPage "740" @default.
- W1991414575 startingPage "733" @default.
- W1991414575 abstract "The aim of the present study was to assess the skin permeation mechanism and bioavailability of celecoxib (CXB) using novel nanoemulsion formulation. Fourier transform infrared spectra and differential scanning calorimetric thermogram of skin treated with nanoemulsion indicated that permeation occurred due to the extraction of stratum corneum (SC) lipids by nanoemulsion. The significant decrease in activation energy for CXB permeation across rat skin indicated that the SC lipid bilayers were significantly disrupted (p < 0.05). Photomicrograph of skin sample showed the disruption and extraction of lipid bilayers as distinct voids and empty spaces visible in the epidermal region. The absorption of CXB through transdermally applied nanoemulsion and nanoemulsion gel resulted in 3.03- and 2.65-fold increases in bioavailability when compared with conventional oral capsule formulation. Overall, these findings indicated that nanoemulsions can be successfully used for the enhancement of skin permeation and bioavailability of poorly soluble drugs." @default.
- W1991414575 created "2016-06-24" @default.
- W1991414575 creator A5025737605 @default.
- W1991414575 creator A5026410761 @default.
- W1991414575 creator A5056421012 @default.
- W1991414575 creator A5077599012 @default.
- W1991414575 creator A5087074970 @default.
- W1991414575 date "2008-01-01" @default.
- W1991414575 modified "2023-09-24" @default.
- W1991414575 title "Celecoxib nanoemulsion: Skin permeation mechanism and bioavailability assessment" @default.
- W1991414575 cites W1204935804 @default.
- W1991414575 cites W1241822319 @default.
- W1991414575 cites W1974008347 @default.
- W1991414575 cites W1980895592 @default.
- W1991414575 cites W1983122413 @default.
- W1991414575 cites W1984008215 @default.
- W1991414575 cites W1984588437 @default.
- W1991414575 cites W1991575888 @default.
- W1991414575 cites W1997325051 @default.
- W1991414575 cites W1998742110 @default.
- W1991414575 cites W2007404282 @default.
- W1991414575 cites W2014101515 @default.
- W1991414575 cites W2017395821 @default.
- W1991414575 cites W2024961974 @default.
- W1991414575 cites W2026537351 @default.
- W1991414575 cites W2035017089 @default.
- W1991414575 cites W2036198080 @default.
- W1991414575 cites W2041887917 @default.
- W1991414575 cites W2067857128 @default.
- W1991414575 cites W2069185355 @default.
- W1991414575 cites W2072725724 @default.
- W1991414575 cites W2075745134 @default.
- W1991414575 cites W2081903916 @default.
- W1991414575 cites W2090729175 @default.
- W1991414575 cites W2100520064 @default.
- W1991414575 cites W2128104791 @default.
- W1991414575 cites W2314290435 @default.
- W1991414575 cites W4235651377 @default.
- W1991414575 cites W91604478 @default.
- W1991414575 doi "https://doi.org/10.1080/10611860802473402" @default.
- W1991414575 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18985507" @default.
- W1991414575 hasPublicationYear "2008" @default.
- W1991414575 type Work @default.
- W1991414575 sameAs 1991414575 @default.
- W1991414575 citedByCount "75" @default.
- W1991414575 countsByYear W19914145752012 @default.
- W1991414575 countsByYear W19914145752013 @default.
- W1991414575 countsByYear W19914145752014 @default.
- W1991414575 countsByYear W19914145752015 @default.
- W1991414575 countsByYear W19914145752016 @default.
- W1991414575 countsByYear W19914145752017 @default.
- W1991414575 countsByYear W19914145752018 @default.
- W1991414575 countsByYear W19914145752019 @default.
- W1991414575 countsByYear W19914145752020 @default.
- W1991414575 countsByYear W19914145752021 @default.
- W1991414575 countsByYear W19914145752022 @default.
- W1991414575 countsByYear W19914145752023 @default.
- W1991414575 crossrefType "journal-article" @default.
- W1991414575 hasAuthorship W1991414575A5025737605 @default.
- W1991414575 hasAuthorship W1991414575A5026410761 @default.
- W1991414575 hasAuthorship W1991414575A5056421012 @default.
- W1991414575 hasAuthorship W1991414575A5077599012 @default.
- W1991414575 hasAuthorship W1991414575A5087074970 @default.
- W1991414575 hasConcept C125287762 @default.
- W1991414575 hasConcept C142724271 @default.
- W1991414575 hasConcept C159985019 @default.
- W1991414575 hasConcept C181389837 @default.
- W1991414575 hasConcept C185592680 @default.
- W1991414575 hasConcept C192562407 @default.
- W1991414575 hasConcept C205679159 @default.
- W1991414575 hasConcept C2777459323 @default.
- W1991414575 hasConcept C2778370115 @default.
- W1991414575 hasConcept C41625074 @default.
- W1991414575 hasConcept C43617362 @default.
- W1991414575 hasConcept C50670333 @default.
- W1991414575 hasConcept C54355233 @default.
- W1991414575 hasConcept C55493867 @default.
- W1991414575 hasConcept C71924100 @default.
- W1991414575 hasConcept C86803240 @default.
- W1991414575 hasConcept C98274493 @default.
- W1991414575 hasConceptScore W1991414575C125287762 @default.
- W1991414575 hasConceptScore W1991414575C142724271 @default.
- W1991414575 hasConceptScore W1991414575C159985019 @default.
- W1991414575 hasConceptScore W1991414575C181389837 @default.
- W1991414575 hasConceptScore W1991414575C185592680 @default.
- W1991414575 hasConceptScore W1991414575C192562407 @default.
- W1991414575 hasConceptScore W1991414575C205679159 @default.
- W1991414575 hasConceptScore W1991414575C2777459323 @default.
- W1991414575 hasConceptScore W1991414575C2778370115 @default.
- W1991414575 hasConceptScore W1991414575C41625074 @default.
- W1991414575 hasConceptScore W1991414575C43617362 @default.
- W1991414575 hasConceptScore W1991414575C50670333 @default.
- W1991414575 hasConceptScore W1991414575C54355233 @default.
- W1991414575 hasConceptScore W1991414575C55493867 @default.
- W1991414575 hasConceptScore W1991414575C71924100 @default.
- W1991414575 hasConceptScore W1991414575C86803240 @default.
- W1991414575 hasConceptScore W1991414575C98274493 @default.
- W1991414575 hasIssue "10" @default.