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- W1991420631 abstract "Exploration for inhibitors against expression of IgE receptor (FcεRI) on human mast cell, a significant trigger to acute and chronic allergic symptoms, disclosed epigallocatechin gallate (EGCG), epicatechin gallate, and gallocatechin gallate as active principles. Additionally, the anthocyanidin, delphinidin, and the flavone, tricetinidin, possessing a pyrogallol function were also revealed to suppress expression of FcεRI. Structure–activity relationship analysis among catechins, anthocyanidins, and flavones revealed the pyrogallol moiety to be crucial for biological potency. Furthermore, EGCG was clarified to reduce generation of γ-chain subunit to suppress expression of FcεRI on human mast cells." @default.
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- W1991420631 date "2010-04-01" @default.
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- W1991420631 title "New inhibitors for expression of IgE receptor on human mast cell" @default.
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- W1991420631 doi "https://doi.org/10.1016/j.bmcl.2010.01.160" @default.
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