FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991422276> ?p ?o ?g. }

• W1991422276 endingPage "921" @default.
• W1991422276 startingPage "911" @default.
• W1991422276 abstract "Under an evolutionary perspective, antigens can be considered nothing else than chronic stressors that constituted the major selective pressure for immune system emergence and evolution. In this review, recent data are discussed under the hypothesis that human immunosenescence is the consequence of the continuous attrition caused by chronic antigenic overload/stress. The advantage of this theoretical approach is that a unifying hypothesis is proposed, which tries to fill in the current gap between the conceptualizations concerning the mechanisms which counteract aging and favor longevity in invertebrates and vertebrates. The hypothesis is that the immune system is, at a higher level of biological organization and complexity, the counterpart of the anti-stress response network identified in invertebrates as the major determinant of survival. We argue that some of the most important characteristics of immunosenescence, i.e. the accumulation and the clonal expansion of memory and effector T cells, the reduction/exhaustion of naive T cells, and the shrinkage of T cell repertoire, are compatible with this assumption. Thus, immunosenescence can be envisaged as a global reduction of the immunological space. Concomitantly, immunosenescence results in the progressive generation of cellular mosaicism which is the consequence of the heterogeneous replicative histories and telomere shortening of T and B cell subsets, as well as hemopoietic stem cells. Most of the parameters affected by immunosenescence appear to be under genetic control, and future research on biomarkers should address this point. On the whole, immunosenescence can be taken as a proof that the beneficial effects of the immune system, devoted to the neutralization of dangerous/harmful agents early in life and in adulthood, turn to be detrimental late in life, in a period largely not foreseen by evolution. This perspective fits with basic assumptions of evolutionary theories of aging, such as antagonistic pleiotropy." @default.
• W1991422276 created "2016-06-24" @default.
• W1991422276 creator A5028945799 @default.
• W1991422276 creator A5030785284 @default.
• W1991422276 creator A5055713485 @default.
• W1991422276 creator A5078302741 @default.
• W1991422276 creator A5081519833 @default.
• W1991422276 date "1999-12-01" @default.
• W1991422276 modified "2023-10-18" @default.
• W1991422276 title "Biomarkers of immunosenescence within an evolutionary perspective: the challenge of heterogeneity and the role of antigenic load" @default.
• W1991422276 cites W14113496 @default.
• W1991422276 cites W1580217007 @default.
• W1991422276 cites W1599040652 @default.
• W1991422276 cites W1612842202 @default.
• W1991422276 cites W1917926680 @default.
• W1991422276 cites W1940197145 @default.
• W1991422276 cites W1963990081 @default.
• W1991422276 cites W1965421615 @default.
• W1991422276 cites W1973389038 @default.
• W1991422276 cites W1975334114 @default.
• W1991422276 cites W1976273464 @default.
• W1991422276 cites W1977724378 @default.
• W1991422276 cites W1981949435 @default.
• W1991422276 cites W1983991488 @default.
• W1991422276 cites W1990878452 @default.
• W1991422276 cites W1995239001 @default.
• W1991422276 cites W2002299348 @default.
• W1991422276 cites W2021722652 @default.
• W1991422276 cites W2027618021 @default.
• W1991422276 cites W2030414136 @default.
• W1991422276 cites W2033817379 @default.
• W1991422276 cites W2039868031 @default.
• W1991422276 cites W2040601774 @default.
• W1991422276 cites W2048882561 @default.
• W1991422276 cites W2054893928 @default.
• W1991422276 cites W2064651531 @default.
• W1991422276 cites W2068409711 @default.
• W1991422276 cites W2072622521 @default.
• W1991422276 cites W2075340810 @default.
• W1991422276 cites W2079501748 @default.
• W1991422276 cites W2082291199 @default.
• W1991422276 cites W2084237578 @default.
• W1991422276 cites W2084542413 @default.
• W1991422276 cites W2084850697 @default.
• W1991422276 cites W2089500922 @default.
• W1991422276 cites W2096689382 @default.
• W1991422276 cites W2109452057 @default.
• W1991422276 cites W2113078618 @default.
• W1991422276 cites W2117623957 @default.
• W1991422276 cites W2126913017 @default.
• W1991422276 cites W2128951266 @default.
• W1991422276 cites W2142294933 @default.
• W1991422276 cites W2153094950 @default.
• W1991422276 cites W2167779784 @default.
• W1991422276 cites W2291689896 @default.
• W1991422276 cites W2470811529 @default.
• W1991422276 cites W3502285 @default.
• W1991422276 cites W6689149 @default.
• W1991422276 doi "https://doi.org/10.1016/s0531-5565(99)00068-6" @default.
• W1991422276 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10673145" @default.
• W1991422276 hasPublicationYear "1999" @default.
• W1991422276 type Work @default.
• W1991422276 sameAs 1991422276 @default.
• W1991422276 citedByCount "134" @default.
• W1991422276 countsByYear W19914222762012 @default.
• W1991422276 countsByYear W19914222762013 @default.
• W1991422276 countsByYear W19914222762014 @default.
• W1991422276 countsByYear W19914222762015 @default.
• W1991422276 countsByYear W19914222762016 @default.
• W1991422276 countsByYear W19914222762017 @default.
• W1991422276 countsByYear W19914222762018 @default.
• W1991422276 countsByYear W19914222762019 @default.
• W1991422276 countsByYear W19914222762020 @default.
• W1991422276 countsByYear W19914222762021 @default.
• W1991422276 countsByYear W19914222762022 @default.
• W1991422276 countsByYear W19914222762023 @default.
• W1991422276 crossrefType "journal-article" @default.
• W1991422276 hasAuthorship W1991422276A5028945799 @default.
• W1991422276 hasAuthorship W1991422276A5030785284 @default.
• W1991422276 hasAuthorship W1991422276A5055713485 @default.
• W1991422276 hasAuthorship W1991422276A5078302741 @default.
• W1991422276 hasAuthorship W1991422276A5081519833 @default.
• W1991422276 hasConcept C104317684 @default.
• W1991422276 hasConcept C147483822 @default.
• W1991422276 hasConcept C177336024 @default.
• W1991422276 hasConcept C203014093 @default.
• W1991422276 hasConcept C2779056147 @default.
• W1991422276 hasConcept C54355233 @default.
• W1991422276 hasConcept C78458016 @default.
• W1991422276 hasConcept C86803240 @default.
• W1991422276 hasConcept C8891405 @default.
• W1991422276 hasConceptScore W1991422276C104317684 @default.
• W1991422276 hasConceptScore W1991422276C147483822 @default.
• W1991422276 hasConceptScore W1991422276C177336024 @default.
• W1991422276 hasConceptScore W1991422276C203014093 @default.
• W1991422276 hasConceptScore W1991422276C2779056147 @default.
• W1991422276 hasConceptScore W1991422276C54355233 @default.
• W1991422276 hasConceptScore W1991422276C78458016 @default.

• next