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- W1991423170 abstract "We have previously shown that the hypersensitivity of KB MDR cells to 2-deoxy-D-glucose is associated with diminished plasma membrane GLUT-1 levels compared with parental, non-MDR cells. Here we report that MDR cells are hypersensitive to the N-linked glycosylation inhibitor tunicamycin, which induces partial inhibition of GLUT-1 glycosylation and diminishes GLUT-1-mediated transport. The effect of tunicamycin, which also enhances the hypersensitivity of MDR cells to 2-deoxy-D-glucose, could not be attributed to alterations in P-glycoprotein activity. The use of agents that act synergistically to diminish the level and activity of GLUT-1 in MDR cells may be of clinical potential." @default.
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- W1991423170 date "1997-05-19" @default.
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- W1991423170 title "The human KB multidrug-resistant cell line KB-C1 is hypersensitive to inhibitors of glycosylation" @default.
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- W1991423170 doi "https://doi.org/10.1016/s0304-3835(97)04739-3" @default.
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