FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991426014> ?p ?o ?g. }

• W1991426014 endingPage "1608" @default.
• W1991426014 startingPage "1603" @default.
• W1991426014 abstract "Purpose To verify whether a tumor control probability (TCP) model which mechanistically incorporates acute and chronic hypoxia is able to describe animal in vivo dose–response data, exhibiting tumor reoxygenation. Methods and Materials The investigated TCP model accounts for tumor repopulation, reoxygenation of chronic hypoxia, and fluctuating oxygenation of acute hypoxia. Using the maximum likelihood method, the model is fitted to Fischer-Moulder data on Wag/Rij rats, inoculated with rat rhabdomyosarcoma BA1112, and irradiated in vivo using different fractionation schemes. This data set is chosen because two of the experimental dose–response curves exhibit an inverse dose behavior, which is interpreted as due to reoxygenation. The tested TCP model is complex, and therefore, in vivo cell survival data on the same BA1112 cell line from Reinhold were added to Fischer-Moulder data and fitted simultaneously with a corresponding cell survival function. Results The obtained fit to the combined Fischer-Moulder-Reinhold data was statistically acceptable. The best-fit values of the model parameters for which information exists were in the range of published values. The cell survival curves of well-oxygenated and hypoxic cells, computed using the best-fit values of the radiosensitivities and the initial number of clonogens, were in good agreement with the corresponding in vitro and in situ experiments of Reinhold. The best-fit values of most of the hypoxia-related parameters were used to recompute the TCP for non–small cell lung cancer patients as a function of the number of fractions, TCP(n). Conclusions The investigated TCP model adequately describes animal in vivo data exhibiting tumor reoxygenation. The TCP(n) curve computed for non–small cell lung cancer patients with the best-fit values of most of the hypoxia-related parameters confirms previously obtained abrupt reduction in TCP for n < 10, thus warning against the adoption of severely hypofractionated schedules. To verify whether a tumor control probability (TCP) model which mechanistically incorporates acute and chronic hypoxia is able to describe animal in vivo dose–response data, exhibiting tumor reoxygenation. The investigated TCP model accounts for tumor repopulation, reoxygenation of chronic hypoxia, and fluctuating oxygenation of acute hypoxia. Using the maximum likelihood method, the model is fitted to Fischer-Moulder data on Wag/Rij rats, inoculated with rat rhabdomyosarcoma BA1112, and irradiated in vivo using different fractionation schemes. This data set is chosen because two of the experimental dose–response curves exhibit an inverse dose behavior, which is interpreted as due to reoxygenation. The tested TCP model is complex, and therefore, in vivo cell survival data on the same BA1112 cell line from Reinhold were added to Fischer-Moulder data and fitted simultaneously with a corresponding cell survival function. The obtained fit to the combined Fischer-Moulder-Reinhold data was statistically acceptable. The best-fit values of the model parameters for which information exists were in the range of published values. The cell survival curves of well-oxygenated and hypoxic cells, computed using the best-fit values of the radiosensitivities and the initial number of clonogens, were in good agreement with the corresponding in vitro and in situ experiments of Reinhold. The best-fit values of most of the hypoxia-related parameters were used to recompute the TCP for non–small cell lung cancer patients as a function of the number of fractions, TCP(n). The investigated TCP model adequately describes animal in vivo data exhibiting tumor reoxygenation. The TCP(n) curve computed for non–small cell lung cancer patients with the best-fit values of most of the hypoxia-related parameters confirms previously obtained abrupt reduction in TCP for n < 10, thus warning against the adoption of severely hypofractionated schedules." @default.
• W1991426014 created "2016-06-24" @default.
• W1991426014 creator A5055790933 @default.
• W1991426014 creator A5061746429 @default.
• W1991426014 creator A5067525027 @default.
• W1991426014 creator A5081673996 @default.
• W1991426014 date "2012-08-01" @default.
• W1991426014 modified "2023-09-27" @default.
• W1991426014 title "Applying a Hypoxia-Incorporating TCP Model to Experimental Data on Rat Sarcoma" @default.
• W1991426014 cites W1955500944 @default.
• W1991426014 cites W1985894363 @default.
• W1991426014 cites W1991341050 @default.
• W1991426014 cites W1995287452 @default.
• W1991426014 cites W2000156247 @default.
• W1991426014 cites W2013944203 @default.
• W1991426014 cites W2022458244 @default.
• W1991426014 cites W2027652813 @default.
• W1991426014 cites W2029303959 @default.
• W1991426014 cites W2056075055 @default.
• W1991426014 cites W2065191153 @default.
• W1991426014 cites W2070394361 @default.
• W1991426014 cites W2077356383 @default.
• W1991426014 cites W2089253822 @default.
• W1991426014 cites W2111685034 @default.
• W1991426014 cites W2118170166 @default.
• W1991426014 cites W2145616568 @default.
• W1991426014 cites W2167229055 @default.
• W1991426014 doi "https://doi.org/10.1016/j.ijrobp.2011.10.015" @default.
• W1991426014 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22270163" @default.
• W1991426014 hasPublicationYear "2012" @default.
• W1991426014 type Work @default.
• W1991426014 sameAs 1991426014 @default.
• W1991426014 citedByCount "13" @default.
• W1991426014 countsByYear W19914260142013 @default.
• W1991426014 countsByYear W19914260142014 @default.
• W1991426014 countsByYear W19914260142015 @default.
• W1991426014 countsByYear W19914260142016 @default.
• W1991426014 countsByYear W19914260142017 @default.
• W1991426014 countsByYear W19914260142018 @default.
• W1991426014 countsByYear W19914260142020 @default.
• W1991426014 countsByYear W19914260142021 @default.
• W1991426014 countsByYear W19914260142022 @default.
• W1991426014 crossrefType "journal-article" @default.
• W1991426014 hasAuthorship W1991426014A5055790933 @default.
• W1991426014 hasAuthorship W1991426014A5061746429 @default.
• W1991426014 hasAuthorship W1991426014A5067525027 @default.
• W1991426014 hasAuthorship W1991426014A5081673996 @default.
• W1991426014 hasConcept C150903083 @default.
• W1991426014 hasConcept C178790620 @default.
• W1991426014 hasConcept C185592680 @default.
• W1991426014 hasConcept C207001950 @default.
• W1991426014 hasConcept C540031477 @default.
• W1991426014 hasConcept C71924100 @default.
• W1991426014 hasConcept C7836513 @default.
• W1991426014 hasConcept C86803240 @default.
• W1991426014 hasConceptScore W1991426014C150903083 @default.
• W1991426014 hasConceptScore W1991426014C178790620 @default.
• W1991426014 hasConceptScore W1991426014C185592680 @default.
• W1991426014 hasConceptScore W1991426014C207001950 @default.
• W1991426014 hasConceptScore W1991426014C540031477 @default.
• W1991426014 hasConceptScore W1991426014C71924100 @default.
• W1991426014 hasConceptScore W1991426014C7836513 @default.
• W1991426014 hasConceptScore W1991426014C86803240 @default.
• W1991426014 hasIssue "5" @default.
• W1991426014 hasLocation W19914260141 @default.
• W1991426014 hasLocation W19914260142 @default.
• W1991426014 hasOpenAccess W1991426014 @default.
• W1991426014 hasPrimaryLocation W19914260141 @default.
• W1991426014 hasRelatedWork W1995515455 @default.
• W1991426014 hasRelatedWork W2074574421 @default.
• W1991426014 hasRelatedWork W2080531066 @default.
• W1991426014 hasRelatedWork W2117620147 @default.
• W1991426014 hasRelatedWork W2748952813 @default.
• W1991426014 hasRelatedWork W2893729619 @default.
• W1991426014 hasRelatedWork W2899084033 @default.
• W1991426014 hasRelatedWork W3031052312 @default.
• W1991426014 hasRelatedWork W3032375762 @default.
• W1991426014 hasRelatedWork W4364382127 @default.
• W1991426014 hasVolume "83" @default.
• W1991426014 isParatext "false" @default.
• W1991426014 isRetracted "false" @default.
• W1991426014 magId "1991426014" @default.
• W1991426014 workType "article" @default.