Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991427041> ?p ?o ?g. }
- W1991427041 endingPage "1459" @default.
- W1991427041 startingPage "1449" @default.
- W1991427041 abstract "Heparin-induced thrombocytopenia (HIT) is a potentially serious complication of heparin therapy and is being encountered more frequently in patients with cardiovascular disease as use of anticoagulant therapy becomes more widespread. Our understanding of the pathophysiology of this immune-mediated condition has improved in recent years, with heparin–platelet factor 4 complex as the culprit antigen in most patients. New sensitive laboratory assays for the pathogenic antibody are now available and should permit an earlier, more reliable diagnosis, but their optimal application remains to be defined. For patients in whom HIT is diagnosed, immediate discontinuation of heparin infusions and elimination of heparin from all flushes and ports are mandatory. Further management of patients with HIT is problematic at present, as there are no readily available alternative anticoagulant agents in the United States with proven efficacy in acute coronary disease. The direct thrombin inhibitors appear to be the most promising alternatives to heparin, when continued use of heparin is contraindicated, and the results of several multicenter trials evaluating their application in patients with HIT are awaited." @default.
- W1991427041 created "2016-06-24" @default.
- W1991427041 creator A5026341373 @default.
- W1991427041 creator A5029768994 @default.
- W1991427041 creator A5045302681 @default.
- W1991427041 creator A5047977017 @default.
- W1991427041 date "1998-06-01" @default.
- W1991427041 modified "2023-10-18" @default.
- W1991427041 title "Heparin-Induced Thrombocytopenia" @default.
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