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• W1991429524 abstract "Muscle wasting is a prominent feature of end-stage renal disease and is associated with muscle weakness and poor physical functioning. Potential reasons for muscle wasting include advancing age, sedentary behavior, inflammation, poor nutritional intake, androgen deficiency, oxidative stress, metabolic acidosis, and insulin resistance. Each of these conditions can be associated with decreased protein synthesis, increased protein degradation, or both. The primary muscle protein synthesis pathway is the insulin insulin-like growth factor-1/phosphatidyl inositol-3 kinase/Akt pathway, which results in the phosphorylation of the mammalian target of rapamycin and subsequent increased protein synthesis. The major protein degradation pathway is the ubiquitin-proteasome system. This review discusses the ways in which end-stage renal disease tips the balance of protein turnover towards catabolism and the mechanisms by which various interventions may work to mitigate wasting or even cause anabolism. Muscle wasting is a prominent feature of end-stage renal disease and is associated with muscle weakness and poor physical functioning. Potential reasons for muscle wasting include advancing age, sedentary behavior, inflammation, poor nutritional intake, androgen deficiency, oxidative stress, metabolic acidosis, and insulin resistance. Each of these conditions can be associated with decreased protein synthesis, increased protein degradation, or both. The primary muscle protein synthesis pathway is the insulin insulin-like growth factor-1/phosphatidyl inositol-3 kinase/Akt pathway, which results in the phosphorylation of the mammalian target of rapamycin and subsequent increased protein synthesis. The major protein degradation pathway is the ubiquitin-proteasome system. This review discusses the ways in which end-stage renal disease tips the balance of protein turnover towards catabolism and the mechanisms by which various interventions may work to mitigate wasting or even cause anabolism." @default.
• W1991429524 created "2016-06-24" @default.
• W1991429524 creator A5080500263 @default.
• W1991429524 date "2009-11-01" @default.
• W1991429524 modified "2023-10-15" @default.
• W1991429524 title "Anabolic and Catabolic Mechanisms in End-Stage Renal Disease" @default.
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• W1991429524 cites W1965818295 @default.
• W1991429524 cites W1971979157 @default.
• W1991429524 cites W1973127865 @default.
• W1991429524 cites W1974866100 @default.
• W1991429524 cites W1978811843 @default.
• W1991429524 cites W1979819215 @default.
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• W1991429524 cites W1985534077 @default.
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• W1991429524 doi "https://doi.org/10.1053/j.ackd.2009.07.007" @default.
• W1991429524 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19801138" @default.
• W1991429524 hasPublicationYear "2009" @default.
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