FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991435883> ?p ?o ?g. }

• W1991435883 endingPage "620" @default.
• W1991435883 startingPage "619" @default.
• W1991435883 abstract "HbA1c is considered the gold standard on which to base monitoring and treatment decisions in T2DM; nonetheless, it has several limitations, among which is that it represents mainly mean glycemia exposure overtime, whereas optimal diabetes management involves control of fasting, preprandial, and postprandial glucose levels. Thus, an elevated HbA1c measurement signals a need for a change in therapy, but it cannot indicate the type of change. Evidence points to the importance of postprandial hyperglycemia contribution on both macro and microvascular diabetic complications. The availability of a continuous glucose monitoring system (CGMS) offers better opportunity for diabetic patients to manage this condition. Several published studies have aimed at assessing the correlation between HbA1c and glycemia levels at several times of the day. Most of these studies have focused on fasting and preprandial and postprandial glucose levels. The contribution of specific time of the day in T2DM patients to the overall glycemic control has never been studied. Our study is the first investigating the contribution of overnight glycemia to HbA1c levels using CGMS technology.We present a retrospective study on available CGMS data from T2DM patients. CGMS was performed on 84 patients (50 males and 34 females). Patients were divided to 3 subgroups depending on levels of HbA1c. Group 1 patients had an HbA1c level ≤ 8% (mean age, 58 ± 6 years). Group 2 patients had an HbA1c level between 8% and 10% (mean age, 59 ± 8 years), and group 3 patients had an HbA1c level ≥ 10% (mean age, 56 ± 8 years). Duration of diabetes was documented as well as the number of hypoglycemic events defined as episodes of glucose < 50 mg/dl. Weight, BMI, and type of treatment were recorded. Mean glucose levels at different times of the day/night were collected from the data provided by CGMS and categorized into 6 hours periods. Plotting the data (Figure 1) showed that the mean overnight glucose tends to correlate with the extent of diurnal hyperglycemia thus showing a greater contribution of the overnight glycemia to overall daytime glycemia in T2DM patients. In group 1, overnight glucose was significantly lower than the morning, afternoon, and evening glucose. In group 2, mean glucose levels during the morning, afternoon, evening, and overnight were all similar (P < .05). In group 3, mean overnight glucose was significantly higher than mean morning, afternoon, and evening glucose. As a conclusion, we found that overnight glycemia correlated best with both mean daytime glycemia and HbA1c levels, whereas the mean nighttime glycemia was the highest, with the highest HbA1c levels.Figure 1.(A) Group 1 patients with an HBA1C 10%; mean ...This finding is in accordance with the Bonora et al study1 as well as the Borg et al study2 and the Hillman et al study,3 where mean preprandial glucose correlated best with HbA1c when compared with postprandial glucose.Although our study is limited by the small number of patients, it sheds light on the limitations of HbA1c as a sole indicator of diabetes and shows the importance of daily glucose and CGMS in treatment monitoring. Larger studies are needed to better investigate the association between daily glucose and HbA1c." @default.
• W1991435883 created "2016-06-24" @default.
• W1991435883 creator A5003834588 @default.
• W1991435883 creator A5026378787 @default.
• W1991435883 creator A5034327184 @default.
• W1991435883 creator A5074197023 @default.
• W1991435883 date "2014-03-06" @default.
• W1991435883 modified "2023-09-27" @default.
• W1991435883 title "Contributions of Overnight Glycemia to the Overall Hyperglycemia of Type 2 Diabetic Patients" @default.
• W1991435883 cites W2032725587 @default.
• W1991435883 cites W2077702349 @default.
• W1991435883 cites W2148263855 @default.
• W1991435883 doi "https://doi.org/10.1177/1932296814525541" @default.
• W1991435883 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4455441" @default.
• W1991435883 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24876628" @default.
• W1991435883 hasPublicationYear "2014" @default.
• W1991435883 type Work @default.
• W1991435883 sameAs 1991435883 @default.
• W1991435883 citedByCount "1" @default.
• W1991435883 countsByYear W19914358832017 @default.
• W1991435883 crossrefType "journal-article" @default.
• W1991435883 hasAuthorship W1991435883A5003834588 @default.
• W1991435883 hasAuthorship W1991435883A5026378787 @default.
• W1991435883 hasAuthorship W1991435883A5034327184 @default.
• W1991435883 hasAuthorship W1991435883A5074197023 @default.
• W1991435883 hasBestOaLocation W19914358831 @default.
• W1991435883 hasConcept C126322002 @default.
• W1991435883 hasConcept C134018914 @default.
• W1991435883 hasConcept C2777180221 @default.
• W1991435883 hasConcept C2781232474 @default.
• W1991435883 hasConcept C2908918659 @default.
• W1991435883 hasConcept C2986379492 @default.
• W1991435883 hasConcept C555293320 @default.
• W1991435883 hasConcept C71924100 @default.
• W1991435883 hasConceptScore W1991435883C126322002 @default.
• W1991435883 hasConceptScore W1991435883C134018914 @default.
• W1991435883 hasConceptScore W1991435883C2777180221 @default.
• W1991435883 hasConceptScore W1991435883C2781232474 @default.
• W1991435883 hasConceptScore W1991435883C2908918659 @default.
• W1991435883 hasConceptScore W1991435883C2986379492 @default.
• W1991435883 hasConceptScore W1991435883C555293320 @default.
• W1991435883 hasConceptScore W1991435883C71924100 @default.
• W1991435883 hasIssue "3" @default.
• W1991435883 hasLocation W19914358831 @default.
• W1991435883 hasLocation W19914358832 @default.
• W1991435883 hasLocation W19914358833 @default.
• W1991435883 hasLocation W19914358834 @default.
• W1991435883 hasOpenAccess W1991435883 @default.
• W1991435883 hasPrimaryLocation W19914358831 @default.
• W1991435883 hasRelatedWork W1988211537 @default.
• W1991435883 hasRelatedWork W2027785653 @default.
• W1991435883 hasRelatedWork W2148723141 @default.
• W1991435883 hasRelatedWork W2749328425 @default.
• W1991435883 hasRelatedWork W3030724877 @default.
• W1991435883 hasRelatedWork W3133968840 @default.
• W1991435883 hasRelatedWork W3203929004 @default.
• W1991435883 hasRelatedWork W3204224586 @default.
• W1991435883 hasRelatedWork W3205547171 @default.
• W1991435883 hasRelatedWork W4207049476 @default.
• W1991435883 hasVolume "8" @default.
• W1991435883 isParatext "false" @default.
• W1991435883 isRetracted "false" @default.
• W1991435883 magId "1991435883" @default.
• W1991435883 workType "article" @default.