FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991436698> ?p ?o ?g. }

• W1991436698 endingPage "189" @default.
• W1991436698 startingPage "180" @default.
• W1991436698 abstract "Object Clazosentan therapy after aneurysmal subarachnoid hemorrhage (SAH) has been found to be effective in reducing the incidence of vasospasm in randomized controlled trials. However, while vasospasm-related morbidity, including delayed ischemic neurological deficits (DINDs) and delayed cerebral infarctions, was consistently decreased, statistical significance was not demonstrated and outcomes were not affected by clazosentan treatment. The objective of this meta-analysis was to determine whether clazosentan treatment after aneurysmal SAH significantly reduced the incidence of DINDs and delayed cerebral infarctions and improved outcomes. Methods All randomized controlled trials investigating the effect of clazosentan were retrieved via searches with sensitive and specific terms. Six variables were abstracted after the assessment of the methodological quality of the trials. Analyses were performed following the method guidelines of the Cochrane Back Review Group. Results Four randomized, placebo-controlled trials met eligibility criteria, enrolling a total of 2181 patients. The meta-analysis demonstrated a significant decrease in the incidence of DINDs (relative risk [RR] 0.76 [95% CI 0.62–0.92]) and delayed cerebral infarction (RR 0.79 [95% CI 0.63–1.00]) in patients treated with clazosentan after aneurysmal SAH. However, this treatment regimen was not shown to outcomes including functional outcomes measured by Glasgow Outcome Scale-Extended (RR 1.12 [95% CI 0.96–1.30]) or mortality (RR 1.02 [95%CI 0.70–1.49]). Adverse events, including pulmonary complications, anemia, and hypotension, were all significantly increased in patients who received clazosentan therapy. Conclusions The results of the present meta-analysis show that treatment with clazosentan after aneurysmal SAH significantly reduced the incidence of the vasospasm-related DINDs and delayed cerebral infarctions, but did not improve poor neurological outcomes in patients with aneurysmal SAH. Further study is required to elucidate the dissociation between vasospasm-related morbidity and outcomes." @default.
• W1991436698 created "2016-06-24" @default.
• W1991436698 creator A5081754197 @default.
• W1991436698 creator A5082647900 @default.
• W1991436698 creator A5089703921 @default.
• W1991436698 creator A5091292707 @default.
• W1991436698 creator A5091762266 @default.
• W1991436698 date "2013-07-01" @default.
• W1991436698 modified "2023-10-05" @default.
• W1991436698 title "Dissociation of vasospasm-related morbidity and outcomes in patients with aneurysmal subarachnoid hemorrhage treated with clazosentan: a meta-analysis of randomized controlled trials" @default.
• W1991436698 cites W1628962302 @default.
• W1991436698 cites W1902565395 @default.
• W1991436698 cites W1942702256 @default.
• W1991436698 cites W1970555337 @default.
• W1991436698 cites W1973969997 @default.
• W1991436698 cites W1982228885 @default.
• W1991436698 cites W1989124609 @default.
• W1991436698 cites W2000504394 @default.
• W1991436698 cites W2000989334 @default.
• W1991436698 cites W2006101560 @default.
• W1991436698 cites W2013325304 @default.
• W1991436698 cites W2022630683 @default.
• W1991436698 cites W2027913805 @default.
• W1991436698 cites W2030353936 @default.
• W1991436698 cites W2032422408 @default.
• W1991436698 cites W2036741315 @default.
• W1991436698 cites W2038450148 @default.
• W1991436698 cites W2044489109 @default.
• W1991436698 cites W2050554365 @default.
• W1991436698 cites W2064296154 @default.
• W1991436698 cites W2066558585 @default.
• W1991436698 cites W2070070132 @default.
• W1991436698 cites W2071201445 @default.
• W1991436698 cites W2075445803 @default.
• W1991436698 cites W2079405518 @default.
• W1991436698 cites W2087145277 @default.
• W1991436698 cites W2093984243 @default.
• W1991436698 cites W2102182787 @default.
• W1991436698 cites W2104675861 @default.
• W1991436698 cites W2106938293 @default.
• W1991436698 cites W2107328434 @default.
• W1991436698 cites W2115242718 @default.
• W1991436698 cites W2125435699 @default.
• W1991436698 cites W2129132447 @default.
• W1991436698 cites W2148710266 @default.
• W1991436698 cites W2150982420 @default.
• W1991436698 cites W2154601847 @default.
• W1991436698 cites W2171233378 @default.
• W1991436698 cites W2468996569 @default.
• W1991436698 cites W4294810471 @default.
• W1991436698 doi "https://doi.org/10.3171/2013.3.jns121436" @default.
• W1991436698 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23641823" @default.
• W1991436698 hasPublicationYear "2013" @default.
• W1991436698 type Work @default.
• W1991436698 sameAs 1991436698 @default.
• W1991436698 citedByCount "50" @default.
• W1991436698 countsByYear W19914366982014 @default.
• W1991436698 countsByYear W19914366982015 @default.
• W1991436698 countsByYear W19914366982016 @default.
• W1991436698 countsByYear W19914366982017 @default.
• W1991436698 countsByYear W19914366982018 @default.
• W1991436698 countsByYear W19914366982019 @default.
• W1991436698 countsByYear W19914366982020 @default.
• W1991436698 countsByYear W19914366982021 @default.
• W1991436698 countsByYear W19914366982022 @default.
• W1991436698 countsByYear W19914366982023 @default.
• W1991436698 crossrefType "journal-article" @default.
• W1991436698 hasAuthorship W1991436698A5081754197 @default.
• W1991436698 hasAuthorship W1991436698A5082647900 @default.
• W1991436698 hasAuthorship W1991436698A5089703921 @default.
• W1991436698 hasAuthorship W1991436698A5091292707 @default.
• W1991436698 hasAuthorship W1991436698A5091762266 @default.
• W1991436698 hasConcept C126322002 @default.
• W1991436698 hasConcept C142724271 @default.
• W1991436698 hasConcept C168563851 @default.
• W1991436698 hasConcept C17624336 @default.
• W1991436698 hasConcept C204787440 @default.
• W1991436698 hasConcept C27081682 @default.
• W1991436698 hasConcept C2776820941 @default.
• W1991436698 hasConcept C2777736543 @default.
• W1991436698 hasConcept C2777796830 @default.
• W1991436698 hasConcept C2778506911 @default.
• W1991436698 hasConcept C42219234 @default.
• W1991436698 hasConcept C44249647 @default.
• W1991436698 hasConcept C71924100 @default.
• W1991436698 hasConcept C82789193 @default.
• W1991436698 hasConcept C95190672 @default.
• W1991436698 hasConceptScore W1991436698C126322002 @default.
• W1991436698 hasConceptScore W1991436698C142724271 @default.
• W1991436698 hasConceptScore W1991436698C168563851 @default.
• W1991436698 hasConceptScore W1991436698C17624336 @default.
• W1991436698 hasConceptScore W1991436698C204787440 @default.
• W1991436698 hasConceptScore W1991436698C27081682 @default.
• W1991436698 hasConceptScore W1991436698C2776820941 @default.
• W1991436698 hasConceptScore W1991436698C2777736543 @default.
• W1991436698 hasConceptScore W1991436698C2777796830 @default.
• W1991436698 hasConceptScore W1991436698C2778506911 @default.
• W1991436698 hasConceptScore W1991436698C42219234 @default.

• next