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- W1991437032 abstract "The glycosyltransferase AveBI, which is involved in the biosynthesis of the macrolide antihelmintic avermectin (AVM), was characterized in vitro. AveBI was confirmed to catalyze two separate iterative additions of l-oleandrose, and the reversibility of AveBI-catalyzed reaction was also demonstrated. Investigation of sugar nucleotide specificity revealed 10 unique sugar nucleotide substrates which, in combination with five distinct aglycones, led to the production of 50 differentially glycosylated AVM variants." @default.
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- W1991437032 date "2006-12-01" @default.
- W1991437032 modified "2023-10-07" @default.
- W1991437032 title "The in Vitro Characterization of the Iterative Avermectin Glycosyltransferase AveBI Reveals Reaction Reversibility and Sugar Nucleotide Flexibility" @default.
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- W1991437032 doi "https://doi.org/10.1021/ja065950k" @default.
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