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• W1991439451 startingPage "458" @default.
• W1991439451 abstract "Abstract The frontonasal mass gives rise to the facial midline and fuses with the maxillary prominence to form the upper lip. Here we focus on the regulation and function of TBX22 , a repressor dynamically expressed in the frontonasal mass. Both FGF and Noggin (a BMP antagonist) strongly induce gTBX22 , however, each has opposite effects on morphogenesis ‐ Noggin inhibits whereas FGF stimulates growth. To determine whether TBX22 mediates these effects, we used retroviruses to locally increase expression levels. RCAS:: hTBX22 decreased proliferation, reduced expression of MSX2 and DLX5 and caused cleft lip. Decreased levels of endogenous gTBX22 were also observed but were not the primary cause of the phenotype as determined in rescue experiments. Our data suggest that genetic or environmental insults such as those affecting the BMP pathway could lead to a gain‐of‐function of TBX22 and predispose an individual to cleft lip. Developmental Dynamics 239:458–473, 2010. © 2009 Wiley‐Liss, Inc." @default.
• W1991439451 created "2016-06-24" @default.
• W1991439451 creator A5055178879 @default.
• W1991439451 creator A5062991850 @default.
• W1991439451 creator A5072904956 @default.
• W1991439451 date "2010-01-22" @default.
• W1991439451 modified "2023-10-18" @default.
• W1991439451 title "The function and regulation of TBX22 in avian frontonasal morphogenesis" @default.
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• W1991439451 doi "https://doi.org/10.1002/dvdy.22182" @default.
• W1991439451 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20033915" @default.
• W1991439451 hasPublicationYear "2010" @default.
• W1991439451 type Work @default.

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