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• W1991443884 abstract "Pyrrolo[3,4-c]carbazoles bearing solubilising basic side chains at the 8-position retain potent Wee1 and Chk1 inhibitory properties in isolated enzyme assays, and evidence of G2/M checkpoint abrogation in several cellular assays. Co-crystal structure studies confirm that the primary binding to the Wee1 enzyme is as described previously, with the C-8 side chains residing in an area of bulk tolerance." @default.
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• W1991443884 date "2008-02-01" @default.
• W1991443884 modified "2023-10-16" @default.
• W1991443884 title "Synthesis and structure–activity relationships of soluble 8-substituted 4-(2-chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of the Wee1 and Chk1 checkpoint kinases" @default.
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• W1991443884 doi "https://doi.org/10.1016/j.bmcl.2007.12.046" @default.
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