Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991444172> ?p ?o ?g. }
- W1991444172 endingPage "1630" @default.
- W1991444172 startingPage "1621" @default.
- W1991444172 abstract "Recent reports have suggested a role for group II metabotropic glutamate receptors (mGluRs) in the attenuation of excitotoxicity. Here we examined the effects of the recently available group II agonist (+)-2-Aminobicyclo[3.1.0]hexane-2-6-dicarboxylic acid (LY354740) on N-methyl-d-aspartate (NMDA)-induced excitotoxic neuronal death, as well as on hypoxic-ischemic neuronal death both in vitro and in vivo. At concentrations shown to be selective for group II mGluRs expressed in cell lines (0.1–100 nM), LY354740 did not attenuate NMDA-mediated neuronal death in vitro or in vivo. Furthermore, LY354740 did not attenuate oxygen-glucose deprivation-induced neuronal death in vitro or ischemic infarction after transient middle cerebral artery occlusion in rats. In addition, the neuroprotective effect of another group II agonist, (S)-4-carboxy-3-phenylglycine (4C3HPG), which has shown injury attenuating effects both in vitro and in vivo, was not blocked by the group II antagonists (2 S)-α-ethylglutamic acid (EGLU), (RS)-α-methyl-4-sulphonophenylglycine (MSPG), or the group III antagonist (S)-α-methyl-3-carboxyphenylalanine (MCPA), suggesting that this neuroprotection may be mediated by other effects such as upon group I mGluRs." @default.
- W1991444172 created "2016-06-24" @default.
- W1991444172 creator A5020066988 @default.
- W1991444172 creator A5045430644 @default.
- W1991444172 creator A5066110360 @default.
- W1991444172 creator A5070542745 @default.
- W1991444172 creator A5072552462 @default.
- W1991444172 creator A5076769455 @default.
- W1991444172 creator A5078262413 @default.
- W1991444172 creator A5091048537 @default.
- W1991444172 date "1999-10-01" @default.
- W1991444172 modified "2023-10-18" @default.
- W1991444172 title "Selective activation of group II mGluRs with LY354740 does not prevent neuronal excitotoxicity" @default.
- W1991444172 cites W1487123995 @default.
- W1991444172 cites W1489966545 @default.
- W1991444172 cites W1491096799 @default.
- W1991444172 cites W1509785349 @default.
- W1991444172 cites W1891815016 @default.
- W1991444172 cites W1950417202 @default.
- W1991444172 cites W1966045367 @default.
- W1991444172 cites W1968185291 @default.
- W1991444172 cites W1969505763 @default.
- W1991444172 cites W1970596941 @default.
- W1991444172 cites W1971306714 @default.
- W1991444172 cites W1971672986 @default.
- W1991444172 cites W1981993146 @default.
- W1991444172 cites W1982543967 @default.
- W1991444172 cites W1983515232 @default.
- W1991444172 cites W1983664266 @default.
- W1991444172 cites W1988086690 @default.
- W1991444172 cites W1988657739 @default.
- W1991444172 cites W1991589969 @default.
- W1991444172 cites W1995311079 @default.
- W1991444172 cites W2001833774 @default.
- W1991444172 cites W2009311043 @default.
- W1991444172 cites W2010428345 @default.
- W1991444172 cites W2011212122 @default.
- W1991444172 cites W2016575029 @default.
- W1991444172 cites W2018421841 @default.
- W1991444172 cites W2021671423 @default.
- W1991444172 cites W2028152919 @default.
- W1991444172 cites W2029533997 @default.
- W1991444172 cites W2031010234 @default.
- W1991444172 cites W2033745315 @default.
- W1991444172 cites W2035574548 @default.
- W1991444172 cites W2038583417 @default.
- W1991444172 cites W2038789824 @default.
- W1991444172 cites W2043166209 @default.
- W1991444172 cites W2045484346 @default.
- W1991444172 cites W2046996969 @default.
- W1991444172 cites W2048661219 @default.
- W1991444172 cites W2052940612 @default.
- W1991444172 cites W2060714812 @default.
- W1991444172 cites W2063675915 @default.
- W1991444172 cites W2068761941 @default.
- W1991444172 cites W2071176474 @default.
- W1991444172 cites W2077288868 @default.
- W1991444172 cites W2078199061 @default.
- W1991444172 cites W2079592194 @default.
- W1991444172 cites W2084660104 @default.
- W1991444172 cites W2085273994 @default.
- W1991444172 cites W2088435955 @default.
- W1991444172 cites W2097293665 @default.
- W1991444172 cites W2106042714 @default.
- W1991444172 cites W2114600277 @default.
- W1991444172 cites W2115217673 @default.
- W1991444172 cites W2125283476 @default.
- W1991444172 cites W2141238764 @default.
- W1991444172 cites W2149954442 @default.
- W1991444172 cites W2153450997 @default.
- W1991444172 cites W2159484326 @default.
- W1991444172 cites W2166615294 @default.
- W1991444172 cites W2277185635 @default.
- W1991444172 cites W4322703206 @default.
- W1991444172 doi "https://doi.org/10.1016/s0028-3908(99)00098-2" @default.
- W1991444172 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10530823" @default.
- W1991444172 hasPublicationYear "1999" @default.
- W1991444172 type Work @default.
- W1991444172 sameAs 1991444172 @default.
- W1991444172 citedByCount "27" @default.
- W1991444172 countsByYear W19914441722013 @default.
- W1991444172 countsByYear W19914441722017 @default.
- W1991444172 countsByYear W19914441722022 @default.
- W1991444172 crossrefType "journal-article" @default.
- W1991444172 hasAuthorship W1991444172A5020066988 @default.
- W1991444172 hasAuthorship W1991444172A5045430644 @default.
- W1991444172 hasAuthorship W1991444172A5066110360 @default.
- W1991444172 hasAuthorship W1991444172A5070542745 @default.
- W1991444172 hasAuthorship W1991444172A5072552462 @default.
- W1991444172 hasAuthorship W1991444172A5076769455 @default.
- W1991444172 hasAuthorship W1991444172A5078262413 @default.
- W1991444172 hasAuthorship W1991444172A5091048537 @default.
- W1991444172 hasConcept C150903083 @default.
- W1991444172 hasConcept C169760540 @default.
- W1991444172 hasConcept C170493617 @default.
- W1991444172 hasConcept C185592680 @default.
- W1991444172 hasConcept C202751555 @default.
- W1991444172 hasConcept C207001950 @default.