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- W1991448105 abstract "Alcohol dehydrogenase-I (ADH-I; EC 1.1.1.1) derived from horse -liver stimulated IgM production by human-human hybridoma, HB4C5 cells and human peripheral blood lymphocytes. The immunoglobulin production stimulating activity of ADH-I was inactivated by chymotrypsin digestion, even though the enzymatic activity was completely preserved. This fact suggests that the immunoglobulin production stimulating effect of ADH-I is irrelevant to its enzymatic function. This also means that the effect is a novel function of this enzyme. ADH-I enhanced IgM production by transcription-suppressed HB4C5 cells treated with actinomycin D. Moreover, the enzyme was effective to accelerate IgM production by translation-suppressed HB4C5 cells treated with sodium fluoride and cycloheximide. Although the secretion of IgM by HB4C5 cells treated with monensin for suppression of the post-transcription process was inhibited, the intracellular IgM content of the cells was obviously increased by the addition of ADH-I. It is supposed from these results that ADH-I accelerates the translation activity to enhance immunoglobulin productivity. In addition, a laser confocal microscopic analysis revealed that ADH-I from horse liver was subsequently incorporated by HB4C5 cells." @default.
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- W1991448105 date "2001-08-01" @default.
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- W1991448105 title "Alcohol dehydrogenase-I from horse liver serves as an immunoglobulin production stimulating factor" @default.
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- W1991448105 doi "https://doi.org/10.1016/s0141-0229(01)00371-4" @default.
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