Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991451475> ?p ?o ?g. }
- W1991451475 abstract "We investigate the importance of the trigger sequence in the folding and dimerization of the GCN4 leucine zipper. We examine the role of the enhanced propensity of the amino acids in the trigger sequence to form an α-helix. Using computer simulations, we calculate heat capacities, free energy profiles, and the probability for successful dimerization as a function of the strength of the α-helical propensity of the trigger sequence. Our results elucidate the experimentally observed importance of the trigger sequence for dimerization and why it is not necessary for the trigger to have a specific “consensus” sequence of amino acids. We also find that a stronger trigger sequence not only increases the probability for dimerization but also changes the dimerization dynamics by introducing multiple intermediate states." @default.
- W1991451475 created "2016-06-24" @default.
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- W1991451475 date "2008-11-07" @default.
- W1991451475 modified "2023-09-24" @default.
- W1991451475 title "The trigger sequence in the GCN4 leucine zipper: α-helical propensity and multistate dynamics of folding and dimerization" @default.
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- W1991451475 doi "https://doi.org/10.1063/1.3006421" @default.
- W1991451475 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19045375" @default.
- W1991451475 hasPublicationYear "2008" @default.
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