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- W1991451880 abstract "Luciferase transgenic mice are a very promising tool for noninvasive, quantitative, and longitudinal evaluation of gene expression. The aim of this study was to validate the Col(I)-Luc transgenic mouse model in which the luciferase gene is driven by bone-specific regulatory elements from the mouse collagen α1(I) gene for bioluminescent imaging of bone development and remodeling. We observed strong luciferase activity in skeletal tissues of Col(I)-Luc mice, and observed that the light intensity declined with postnatal bone development. Luciferase activity was enhanced in a tail bone repair model and we were able to monitor the process of ectopic bone formation induced by recombinant human bone morphogenetic protein 2 using bioluminescent imaging. We conclude that Col(I)-Luc transgenic mice can be applied in the field of bone tissue engineering for monitoring bone repair processes and for investigating osteoinductive molecules or scaffolds." @default.
- W1991451880 created "2016-06-24" @default.
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- W1991451880 date "2010-12-01" @default.
- W1991451880 modified "2023-09-27" @default.
- W1991451880 title "Noninvasive Imaging of Bone-Specific Collagen I Expression in a Luciferase Transgenic Mouse Model" @default.
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- W1991451880 doi "https://doi.org/10.1089/ten.tec.2009.0594" @default.
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