FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991453067> ?p ?o ?g. }

• W1991453067 endingPage "997" @default.
• W1991453067 startingPage "987" @default.
• W1991453067 abstract "The combination of tetracaine, epinephrine, and cocaine has gained wide acceptance as a topical anesthetic agent for use on pediatric dermal lacerations in the ED. This is despite the fact that the optimal dose and formulation have yet to be determined. TAC can be applied painlessly to wounds and is about as effective as lidocaine infiltration for anesthetizing pediatric facial and scalp lacerations. It is relatively ineffective on lacerations located elsewhere or in adults. The most commonly used TAC solution contains high concentrations of cocaine, tetracaine, and epinephrine, drugs that individually can cause serious toxicity if absorbed in sufficient amounts. In addition, the three components of TAC may interact to potentiate their intrinsic toxicities. The deliberate and inadvertent application of TAC to mucous membranes has caused status epilepticus and two pediatric deaths. The risk of toxicity from misapplication of TAC is heightened because TAC is most effective and therefore most widely used on pediatric facial and scalp lacerations. Cocaine is also absorbed after TAC is applied to dermal lacerations and may cause toxicity by this route. Until additional research is performed to establish the minimum effective dose of TAC and its potential toxicity and until FDA approval is granted, we do not think that it can be recommended as the drug of choice for pediatric facial and scalp lacerations in the ED. If TAC is administered, a maximum dose of 2 to 3 mL of the half-strength formula proposed by Bonadio and Wagner should be used, and application should be performed by medical personnel, using a soaked gauze or cotton ball. Care should be taken to make sure none of the solution comes in contact with mucous membranes, and TAC should not be applied to lacerations involving the vermillion border of the lip or the lip itself. Close medical monitoring of the patient is essential to detect signs of toxicity. Research on other topical agents such as tetracaine with epinephrine is also needed. Although anesthetizing wounds painlessly remains a worthy goal, exposing patients to added and unknown risks and increasing the cost of health care is unacceptable." @default.
• W1991453067 created "2016-06-24" @default.
• W1991453067 creator A5087806772 @default.
• W1991453067 creator A5091082299 @default.
• W1991453067 date "1992-08-01" @default.
• W1991453067 modified "2023-10-15" @default.
• W1991453067 title "Use of tetracaine, epinephrine, and cocaine as a topical anesthetic in the emergency department" @default.
• W1991453067 cites W1485892499 @default.
• W1991453067 cites W173952205 @default.
• W1991453067 cites W1913147314 @default.
• W1991453067 cites W1975724001 @default.
• W1991453067 cites W1976870178 @default.
• W1991453067 cites W1981904455 @default.
• W1991453067 cites W1983047160 @default.
• W1991453067 cites W1984141783 @default.
• W1991453067 cites W1984167395 @default.
• W1991453067 cites W1994592390 @default.
• W1991453067 cites W1997825378 @default.
• W1991453067 cites W1998815052 @default.
• W1991453067 cites W2002394364 @default.
• W1991453067 cites W2004330361 @default.
• W1991453067 cites W2005091390 @default.
• W1991453067 cites W2008075059 @default.
• W1991453067 cites W2008129307 @default.
• W1991453067 cites W2009950007 @default.
• W1991453067 cites W2010468116 @default.
• W1991453067 cites W2010635056 @default.
• W1991453067 cites W2013904943 @default.
• W1991453067 cites W2015991409 @default.
• W1991453067 cites W2020296599 @default.
• W1991453067 cites W2021086507 @default.
• W1991453067 cites W2022399868 @default.
• W1991453067 cites W2023194103 @default.
• W1991453067 cites W2030668773 @default.
• W1991453067 cites W2036431361 @default.
• W1991453067 cites W2038379349 @default.
• W1991453067 cites W2040974357 @default.
• W1991453067 cites W2040991636 @default.
• W1991453067 cites W2045353355 @default.
• W1991453067 cites W2050691698 @default.
• W1991453067 cites W2053217148 @default.
• W1991453067 cites W2054467580 @default.
• W1991453067 cites W2056285815 @default.
• W1991453067 cites W2057036307 @default.
• W1991453067 cites W2075002644 @default.
• W1991453067 cites W2075360586 @default.
• W1991453067 cites W2076349595 @default.
• W1991453067 cites W2078955034 @default.
• W1991453067 cites W2081822897 @default.
• W1991453067 cites W2083144553 @default.
• W1991453067 cites W2084583842 @default.
• W1991453067 cites W2086972668 @default.
• W1991453067 cites W2087913919 @default.
• W1991453067 cites W2089165360 @default.
• W1991453067 cites W2093364826 @default.
• W1991453067 cites W2093411410 @default.
• W1991453067 cites W2094799418 @default.
• W1991453067 cites W2095024180 @default.
• W1991453067 cites W2103760626 @default.
• W1991453067 cites W2104455736 @default.
• W1991453067 cites W2105045280 @default.
• W1991453067 cites W2106266041 @default.
• W1991453067 cites W2108522043 @default.
• W1991453067 cites W2119225805 @default.
• W1991453067 cites W2121697442 @default.
• W1991453067 cites W2124185333 @default.
• W1991453067 cites W2143235514 @default.
• W1991453067 cites W2148427931 @default.
• W1991453067 cites W2159844922 @default.
• W1991453067 cites W2166003679 @default.
• W1991453067 cites W2276629573 @default.
• W1991453067 cites W2316853010 @default.
• W1991453067 cites W2325061051 @default.
• W1991453067 cites W2412971445 @default.
• W1991453067 cites W2414178748 @default.
• W1991453067 cites W2417209600 @default.
• W1991453067 cites W2465874329 @default.
• W1991453067 cites W2614758074 @default.
• W1991453067 cites W270755921 @default.
• W1991453067 cites W3026207979 @default.
• W1991453067 cites W4233797463 @default.
• W1991453067 cites W4245425254 @default.
• W1991453067 cites W4253700686 @default.
• W1991453067 cites W1967720044 @default.
• W1991453067 cites W1990702204 @default.
• W1991453067 doi "https://doi.org/10.1016/s0196-0644(05)82942-7" @default.
• W1991453067 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1497171" @default.
• W1991453067 hasPublicationYear "1992" @default.
• W1991453067 type Work @default.
• W1991453067 sameAs 1991453067 @default.
• W1991453067 citedByCount "39" @default.
• W1991453067 countsByYear W19914530672013 @default.
• W1991453067 countsByYear W19914530672017 @default.
• W1991453067 countsByYear W19914530672019 @default.
• W1991453067 countsByYear W19914530672023 @default.
• W1991453067 crossrefType "journal-article" @default.
• W1991453067 hasAuthorship W1991453067A5087806772 @default.
• W1991453067 hasAuthorship W1991453067A5091082299 @default.

• next