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- W1991459478 endingPage "1322" @default.
- W1991459478 startingPage "1311" @default.
- W1991459478 abstract "Silent information regulator-2 (Sir-2) proteins, or sirtuins, are a highly conserved protein family of histone deacetylases that promote longevity by mediating many of the beneficial effects of calorie restriction which extends life span and reduces the incidence of cancer, cardiovascular disease (CVD), and diabetes. Here, we review the role of sirtuins (SIRT1-7) in vascular homeostasis and diseases by providing an update on the latest knowledge about their roles in endothelial damage and vascular repair mechanisms. Among all sirtuins, in the light of the numerous functions reported on SIRT1 in the vascular system, herein we discuss its roles not only in the control of endothelial cells (EC) functionality but also in other cell types beyond EC, including endothelial progenitor cells (EPC), smooth muscle cells (SMC), and immune cells. Furthermore, we also provide an update on the growing field of compounds under clinical evaluation for the modulation of SIRT1 which, at the state of the art, represents the most promising target for the development of novel drugs against CVD, especially when concomitant with type 2 diabetes." @default.
- W1991459478 created "2016-06-24" @default.
- W1991459478 creator A5034109738 @default.
- W1991459478 creator A5041337705 @default.
- W1991459478 creator A5045229210 @default.
- W1991459478 creator A5054367284 @default.
- W1991459478 creator A5058570484 @default.
- W1991459478 creator A5064449233 @default.
- W1991459478 date "2015-07-01" @default.
- W1991459478 modified "2023-10-18" @default.
- W1991459478 title "Sirtuins in vascular diseases: Emerging roles and therapeutic potential" @default.
- W1991459478 cites W1481670920 @default.
- W1991459478 cites W1522380508 @default.
- W1991459478 cites W1847884533 @default.
- W1991459478 cites W1849187416 @default.
- W1991459478 cites W1964041100 @default.
- W1991459478 cites W1964059126 @default.
- W1991459478 cites W1965575508 @default.
- W1991459478 cites W1968884794 @default.
- W1991459478 cites W1972924731 @default.
- W1991459478 cites W1973549141 @default.
- W1991459478 cites W1977244638 @default.
- W1991459478 cites W1978327824 @default.
- W1991459478 cites W1978900120 @default.
- W1991459478 cites W1979495191 @default.
- W1991459478 cites W1980288154 @default.
- W1991459478 cites W1981070369 @default.
- W1991459478 cites W1983465246 @default.
- W1991459478 cites W1985802000 @default.
- W1991459478 cites W1986501172 @default.
- W1991459478 cites W1989919190 @default.
- W1991459478 cites W1990247274 @default.
- W1991459478 cites W1991731804 @default.
- W1991459478 cites W1994328569 @default.
- W1991459478 cites W1995175684 @default.
- W1991459478 cites W1995188356 @default.
- W1991459478 cites W1995520713 @default.
- W1991459478 cites W1996516864 @default.
- W1991459478 cites W1997654090 @default.
- W1991459478 cites W2000197687 @default.
- W1991459478 cites W2000777302 @default.
- W1991459478 cites W2001382962 @default.
- W1991459478 cites W2008062232 @default.
- W1991459478 cites W2013636493 @default.
- W1991459478 cites W2014346023 @default.
- W1991459478 cites W2020311873 @default.
- W1991459478 cites W2025128457 @default.
- W1991459478 cites W2029801763 @default.
- W1991459478 cites W2032175124 @default.
- W1991459478 cites W2034089732 @default.
- W1991459478 cites W2035537647 @default.
- W1991459478 cites W2036526259 @default.
- W1991459478 cites W2038881106 @default.
- W1991459478 cites W2040256946 @default.
- W1991459478 cites W2040625305 @default.
- W1991459478 cites W2041959419 @default.
- W1991459478 cites W2042716686 @default.
- W1991459478 cites W2043966716 @default.
- W1991459478 cites W2044836637 @default.
- W1991459478 cites W2050551286 @default.
- W1991459478 cites W2053804573 @default.
- W1991459478 cites W2055019461 @default.
- W1991459478 cites W2055478739 @default.
- W1991459478 cites W2055539528 @default.
- W1991459478 cites W2061235883 @default.
- W1991459478 cites W2062333262 @default.
- W1991459478 cites W2064013573 @default.
- W1991459478 cites W2064044812 @default.
- W1991459478 cites W2065195323 @default.
- W1991459478 cites W2065705781 @default.
- W1991459478 cites W2066674982 @default.
- W1991459478 cites W2066877588 @default.
- W1991459478 cites W2067933433 @default.
- W1991459478 cites W2068223162 @default.
- W1991459478 cites W2073627261 @default.
- W1991459478 cites W2077612517 @default.
- W1991459478 cites W2080290533 @default.
- W1991459478 cites W2082431118 @default.
- W1991459478 cites W2084347969 @default.
- W1991459478 cites W2086025811 @default.
- W1991459478 cites W2087043303 @default.
- W1991459478 cites W2087168227 @default.
- W1991459478 cites W2087330696 @default.
- W1991459478 cites W2087582854 @default.
- W1991459478 cites W2088605334 @default.
- W1991459478 cites W2093087462 @default.
- W1991459478 cites W2094465929 @default.
- W1991459478 cites W2095667500 @default.
- W1991459478 cites W2095997160 @default.
- W1991459478 cites W2099136912 @default.
- W1991459478 cites W2099806958 @default.
- W1991459478 cites W2102635586 @default.
- W1991459478 cites W2106717373 @default.
- W1991459478 cites W2114633799 @default.
- W1991459478 cites W2114803943 @default.
- W1991459478 cites W2115554047 @default.
- W1991459478 cites W2116350182 @default.
- W1991459478 cites W2117165548 @default.